{"id":"W2036472425","doi":"10.1126/science.287.5450.92","title":"Structural Basis of Smad2 Recognition by the Smad Anchor for Receptor Activation","year":2000,"lang":"en","type":"article","venue":"Science","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":295,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"National Cancer Institute","keywords":"SMAD; Receptor; Coiled coil; Phosphorylation; Serine; Signal transduction; Biophysics; Cell biology; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096048,0.0002930251,0.0002026387,0.0001390983,0.0004444276,0.0003829226,0.000364693,0.000381958,0.002439172],"category_scores_gemma":[0.0001869905,0.0001877571,0.0002236798,0.00009678389,0.0002257659,0.0002359999,0.000307458,0.0004669807,0.001460337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003847415,"about_ca_system_score_gemma":0.0002676045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005135628,"about_ca_topic_score_gemma":0.0005536737,"domain_scores_codex":[0.9999245,0.00001161581,0.000003726265,0.00001437607,0.00002436053,0.00002149813],"domain_scores_gemma":[0.9999108,0.00001111867,0.00002142338,0.000005908766,0.00001570859,0.00003495225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006070861,0.0001144509,0.001248508,0.0001754268,0.00002277126,0.001297347,0.00007733348,0.002813904,0.9801972,0.008250632,0.0008168145,0.004378594],"study_design_scores_gemma":[0.0002987837,0.0007407193,0.02060863,0.00006553174,0.00007461647,0.002871607,0.0003249891,0.03122591,0.9068074,0.007432724,0.02948287,0.00006622175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758251,0.003108018,0.009031823,0.0008294741,0.0001828318,0.00003992883,0.0002320195,0.0002148053,0.01053597],"genre_scores_gemma":[0.9949694,0.0009110385,0.001750034,0.0001355951,0.00003922879,0.00001062587,0.0003908803,0.00001540118,0.001777703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002439172,"threshold_uncertainty_score":0.008159816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01601040951627019,"score_gpt":0.2642535300747919,"score_spread":0.2482431205585217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}