{"id":"W2036491506","doi":"10.1007/s11010-011-0910-6","title":"Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood–brain barrier","year":2011,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Banting Research Foundation","keywords":"ABCA1; Efflux; Blood–brain barrier; Probucol; Cholesterol; Endocrinology; Chemistry; Transporter; Tangier disease; Internal medicine; ATP Binding Cassette Transporter 1; Biology; Pharmacology; Biochemistry; Medicine; Central nervous system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004379784,0.000421841,0.0003687011,0.001004983,0.0003270924,0.0006493946,0.0003821001,0.0006674973,0.002731499],"category_scores_gemma":[0.0003899985,0.0003413281,0.000406853,0.000388526,0.0005567828,0.0006151182,0.0003511635,0.001104402,0.0009614363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005231981,"about_ca_system_score_gemma":0.000309864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00142562,"about_ca_topic_score_gemma":0.001244056,"domain_scores_codex":[0.999652,0.00005653772,0.0000323211,0.0000681585,0.00011361,0.00007746148],"domain_scores_gemma":[0.9995127,0.00008943958,0.0001391314,0.00007437769,0.0001153768,0.00006896461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002486927,0.00001535515,0.0003364647,0.00006168276,0.00001287307,0.0001475931,0.00002862909,0.00002147832,0.9969313,0.0007640966,0.0001265722,0.001305261],"study_design_scores_gemma":[0.00002544669,0.0001018533,0.003225246,0.000009371122,0.00003951147,0.0007261578,0.00003237688,0.0003213692,0.9929596,0.0002933152,0.002258737,0.00000698129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669775,0.009504182,0.01380654,0.001454863,0.0001364663,0.00004041092,0.00146755,0.0003967693,0.006215721],"genre_scores_gemma":[0.9860611,0.002500351,0.003744447,0.0001902127,0.00003058134,0.00004404099,0.0009221419,0.00006982616,0.006437263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002731499,"threshold_uncertainty_score":0.009137809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009387925608299947,"score_gpt":0.207853377536155,"score_spread":0.198465451927855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}