{"id":"W2036501511","doi":"10.1254/jphs.08071fp","title":"Long-Term Treatment With Ranirestat (AS-3201), a Potent Aldose Reductase Inhibitor, Suppresses Diabetic Neuropathy and Cataract Formation in Rats","year":2008,"lang":"en","type":"article","venue":"Journal of Pharmacological Sciences","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Medicine; Streptozotocin; Aldose reductase inhibitor; Aldose reductase; Diabetic neuropathy; Diabetes mellitus; Sciatic nerve; Atrophy; Sural nerve; Internal medicine; Polyol pathway; Endocrinology; Cataracts; Ophthalmology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002048941,0.0006623625,0.0006184322,0.000413578,0.0001922363,0.0002251124,0.000354344,0.0003671976,0.0007846887],"category_scores_gemma":[0.0001191803,0.0001953704,0.0004695632,0.0002198898,0.0002775386,0.0003808069,0.0001712391,0.0009015288,0.0002326555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002086068,"about_ca_system_score_gemma":0.0003951582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009782941,"about_ca_topic_score_gemma":0.001915639,"domain_scores_codex":[0.9998834,0.00001553337,0.00001684746,0.00002242577,0.00002239312,0.00003936363],"domain_scores_gemma":[0.9998087,0.00001197223,0.00006441996,0.00001480705,0.00002827506,0.00007192936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00335756,0.001158193,0.0007544964,0.000148077,0.00004881966,0.0001217055,0.00003973093,0.0001764949,0.9871602,0.00007634659,0.00008175949,0.006876599],"study_design_scores_gemma":[0.0005196758,0.02459939,0.01845611,0.00003801603,0.000214649,0.0003667242,0.0001372507,0.001744636,0.9509428,0.0001091508,0.002835997,0.00003568202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975746,0.001278494,0.000502221,0.00004829778,0.00002415682,0.00001652312,0.0001097158,0.00006460836,0.0003814265],"genre_scores_gemma":[0.9933589,0.002245249,0.001307176,0.00006373102,0.00002113861,0.00005828393,0.0004907967,0.00001514078,0.002439493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009782941,"threshold_uncertainty_score":0.002625048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02518084238604578,"score_gpt":0.2967960858223613,"score_spread":0.2716152434363155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}