{"id":"W2036507877","doi":"10.1089/152308604322899422","title":"Distinct Roles of Ca <sup>2+</sup> , Calmodulin, and Protein Kinase C in H <sub>2</sub> O <sub>2</sub> -Induced Activation of ERK1/2, p38 MAPK, and Protein Kinase B Signaling in Vascular Smooth Muscle Cells","year":2004,"lang":"en","type":"article","venue":"Antioxidants and Redox Signaling","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Phosphorylation; MAPK/ERK pathway; Protein kinase A; p38 mitogen-activated protein kinases; Protein kinase B; Kinase; Protein kinase C; Calmodulin; Chemistry; BAPTA; Cell biology; Molecular biology; Biology; Biochemistry; Extracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008199976,0.000455232,0.0006147982,0.0003535446,0.0001589419,0.00005744116,0.0001437965,0.0003989092,0.000003140938],"category_scores_gemma":[0.0001441699,0.00044867,0.0001329148,0.0004188804,0.000222485,0.0000617614,0.0001393582,0.0002971806,6.944867e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004470187,"about_ca_system_score_gemma":0.0001518475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003112825,"about_ca_topic_score_gemma":0.00009735144,"domain_scores_codex":[0.9971688,0.0002251254,0.0009013755,0.0008388367,0.000362876,0.0005030187],"domain_scores_gemma":[0.9988416,0.00003688363,0.000429994,0.0003403619,0.000170032,0.0001811312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002005611,0.0002533942,0.0003071284,0.0004950215,0.00004897855,0.00003905673,0.0003720043,0.005183998,0.9829656,0.00005754553,0.000001483228,0.01007527],"study_design_scores_gemma":[0.002811887,0.0003279199,0.003745851,0.001682636,0.00004046696,0.000003917774,0.0003725763,0.001787847,0.9883123,0.0003721685,0.00004420539,0.0004981977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994926,0.002120117,0.001487495,0.00005819851,0.00001895952,0.001300168,0.00006056731,0.00001804313,0.00001043101],"genre_scores_gemma":[0.9985239,0.0002963944,0.0008383878,0.00003429123,0.00009003609,0.00007829002,0.00007766389,0.00005885993,0.000002194419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009577069,"threshold_uncertainty_score":0.9997965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007670914172095521,"score_gpt":0.2123647379292897,"score_spread":0.2046938237571942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}