{"id":"W2036557993","doi":"10.1002/jcp.22125","title":"Mechanotransduction by endothelial cells is locally generated, direction‐dependent, and ligand‐specific","year":2010,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Mechanotransduction; Cell biology; Signaling proteins; Phosphorylation; Biophysics; Cytoskeleton; Chemistry; Intracellular; Shear force; Integrin; Endothelium; Cell signaling; Transmembrane protein; Signal transduction; Cell; Biology; Receptor; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002102444,0.0001710209,0.0002269252,0.00007728433,0.0001088149,0.00003266281,0.0001579268,0.0002445142,0.00016519],"category_scores_gemma":[0.00001285012,0.0001543611,0.0001553711,0.00005571712,0.00006223946,0.00001415398,0.00004154964,0.0003901972,0.00001275338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009684735,"about_ca_system_score_gemma":0.0000492233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001025472,"about_ca_topic_score_gemma":0.000007507254,"domain_scores_codex":[0.9989752,0.0000678783,0.0003623349,0.0002648635,0.0001302585,0.0001995195],"domain_scores_gemma":[0.9991843,0.00001110267,0.0002678696,0.0002154265,0.0002050063,0.0001163287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403886,0.0001057088,0.000003245806,0.000006162606,0.0000807041,0.000004470811,0.00003085292,0.00001194134,0.9913182,0.0001037555,0.007030453,0.001164081],"study_design_scores_gemma":[0.0005192852,0.0003683305,0.000008750942,0.000004033468,0.00002534192,0.0001722666,0.00002621665,0.00008923577,0.8015776,0.00026436,0.1968191,0.0001254397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792284,0.001136482,0.01633653,0.0001879557,0.002827313,0.00008675449,0.00004026873,0.00000566175,0.0001506324],"genre_scores_gemma":[0.9944636,0.002401285,0.0004428632,0.0002056545,0.001347117,0.000003069558,0.00003994301,0.00002801665,0.001068492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1897887,"threshold_uncertainty_score":0.6294663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004755556690170012,"score_gpt":0.2057390710927748,"score_spread":0.2009835144026048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}