{"id":"W2036557993","doi":"10.1002/jcp.22125","title":"Mechanotransduction by endothelial cells is locally generated, direction‐dependent, and ligand‐specific","year":2010,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Mechanotransduction; Cell biology; Signaling proteins; Phosphorylation; Biophysics; Cytoskeleton; Chemistry; Intracellular; Shear force; Integrin; Endothelium; Cell signaling; Transmembrane protein; Signal transduction; Cell; Biology; Receptor; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001450505,0.000148652,0.000118771,0.0001086687,0.000143211,0.0003101205,0.00008905502,0.0001680323,0.0008730869],"category_scores_gemma":[0.0001304935,0.0001111449,0.0001135755,0.00009997721,0.0001707,0.0001405089,0.0001246471,0.0002761316,0.0002264963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001923634,"about_ca_system_score_gemma":0.0001724125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002599016,"about_ca_topic_score_gemma":0.0005980503,"domain_scores_codex":[0.9998466,0.00003153119,0.000008903497,0.00002640536,0.0000481769,0.00003838313],"domain_scores_gemma":[0.9999367,0.00001016468,0.00001645192,0.000006420227,0.00001414775,0.00001611676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002716022,0.000007788855,0.0001420928,0.00001102282,0.000001664599,0.00001786846,0.000004955593,0.00001727486,0.9984075,0.00005390937,0.00002692261,0.001281864],"study_design_scores_gemma":[0.00003906015,0.000306131,0.01592143,0.00001033178,0.00001278756,0.0003657383,0.00005239881,0.001002229,0.9797197,0.0001349035,0.002425932,0.000009514834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920678,0.002036972,0.003676962,0.0002115698,0.00004678818,0.00001795898,0.00009230029,0.00003697144,0.00181261],"genre_scores_gemma":[0.9970631,0.0006810349,0.001292423,0.00007824096,0.0000187104,0.0000140017,0.00005182945,0.000004478039,0.0007960738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008730869,"threshold_uncertainty_score":0.002920747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004755556690170012,"score_gpt":0.2057390710927748,"score_spread":0.2009835144026048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}