{"id":"W2036569396","doi":"10.1021/bi015830j","title":"Negative Cooperativity Associated with Binding of Multivalent Carbohydrates to Lectins. Thermodynamic Analysis of the “Multivalency Effect”","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Cooperativity; Chemistry; Cooperative binding; Lectin; Isothermal titration calorimetry; Isothermal microcalorimetry; Affinities; Allosteric regulation; Stereochemistry; Binding site; Titration; Biochemistry; Enthalpy; Thermodynamics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002278657,0.0001625915,0.0002575931,0.00008376535,0.00008200493,0.00000992169,0.0002489272,0.000130787,0.000037857],"category_scores_gemma":[0.0007601302,0.0001076164,0.000156688,0.001170579,0.0001373219,0.000002858436,0.0001174528,0.0001060811,9.284946e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004580111,"about_ca_system_score_gemma":0.00009956256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001213934,"about_ca_topic_score_gemma":0.00013129,"domain_scores_codex":[0.9988612,0.0001414227,0.0002076985,0.000309475,0.0002744966,0.0002057012],"domain_scores_gemma":[0.9990147,0.00006907604,0.0001591851,0.0004177924,0.0002687406,0.00007044877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001803859,0.0001111496,0.06122841,0.00001942569,0.000687923,9.673771e-7,0.00006780356,0.0005922395,0.9368181,0.000001121137,0.00001732596,0.000275216],"study_design_scores_gemma":[0.0004902727,0.0002018583,0.07040422,0.00004641518,0.0001379251,0.000001010754,0.00005189881,0.00154269,0.9269882,7.039496e-7,0.00001387484,0.0001208998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984991,0.00006166508,0.0001242553,0.00005394144,0.00001857414,0.0003381163,0.00008531375,0.000007145379,0.0008119189],"genre_scores_gemma":[0.9986541,0.0000132417,0.00004460792,0.00001293153,0.00001629819,0.00003346293,0.00007886629,0.00001408021,0.001132386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009829811,"threshold_uncertainty_score":0.4388471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008218328545299339,"score_gpt":0.2657328226663045,"score_spread":0.2575144941210052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}