{"id":"W2036569396","doi":"10.1021/bi015830j","title":"Negative Cooperativity Associated with Binding of Multivalent Carbohydrates to Lectins. Thermodynamic Analysis of the “Multivalency Effect”","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Cooperativity; Chemistry; Cooperative binding; Lectin; Isothermal titration calorimetry; Isothermal microcalorimetry; Affinities; Allosteric regulation; Stereochemistry; Binding site; Titration; Biochemistry; Enthalpy; Thermodynamics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001364946,0.0004946004,0.0009038527,0.0004775984,0.0004805081,0.0006754601,0.001128331,0.0003698254,0.001055058],"category_scores_gemma":[0.002097494,0.0003682174,0.0006152543,0.0002715613,0.001239641,0.0006918059,0.0006943707,0.0009143758,0.0002434391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001007046,"about_ca_system_score_gemma":0.0003969655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110013,"about_ca_topic_score_gemma":0.001603094,"domain_scores_codex":[0.9985298,0.0002419704,0.00005964631,0.0003015083,0.0006918971,0.0001751752],"domain_scores_gemma":[0.9984959,0.0007966713,0.0002277683,0.0001306247,0.0002259062,0.0001229654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001420345,0.00009015562,0.002774584,0.0001430438,0.00004691011,0.0001306955,0.0001271114,0.001658083,0.9889185,0.001512656,0.0001676831,0.004288551],"study_design_scores_gemma":[0.00002449772,0.0003993209,0.01388064,0.00001345592,0.0000681087,0.0004636539,0.0001047695,0.03632529,0.944335,0.002090456,0.002236632,0.00005816158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738715,0.001637922,0.01990118,0.0003118356,0.0001047495,0.0001457741,0.0001034813,0.0002504876,0.003672964],"genre_scores_gemma":[0.9964423,0.0003090228,0.002244183,0.0001510935,0.00002142147,0.00006903627,0.0000613188,0.00002487202,0.0006768902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001364946,"threshold_uncertainty_score":0.007306695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008218328545299339,"score_gpt":0.2657328226663045,"score_spread":0.2575144941210052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}