{"id":"W2036609932","doi":"10.3389/fpsyt.2013.00110","title":"Epigenomic Mechanisms of Early Adversity and HPA Dysfunction: Considerations for PTSD Research","year":2013,"lang":"en","type":"review","venue":"Frontiers in Psychiatry","topic":"Birth, Development, and Health","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Epigenomics; Psychology; Neglect; Clinical psychology; Neuroscience; Developmental psychology; Psychiatry; DNA methylation; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009605569,0.0002542993,0.001393002,0.0007434698,0.0002366303,0.00001985013,0.0001052086,0.0004858531,0.00008329588],"category_scores_gemma":[0.0000854488,0.0002298845,0.0001969667,0.0003062921,0.0001492105,0.00007457197,0.00005470214,0.0007062577,0.00001866796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002597398,"about_ca_system_score_gemma":0.002647036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008138426,"about_ca_topic_score_gemma":0.00008171384,"domain_scores_codex":[0.997961,0.0001704285,0.0007057211,0.0004805565,0.0002658,0.0004164447],"domain_scores_gemma":[0.9988567,0.0001266346,0.0002527135,0.0003783517,0.0001876123,0.0001980287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001413118,0.0003144944,0.005013861,0.06176304,0.0005864903,0.00000542903,0.0005731341,9.169076e-8,9.910137e-7,0.1144298,0.6278549,0.1893164],"study_design_scores_gemma":[0.003576376,0.001055588,0.00206373,0.01244595,0.0008624115,0.0000762306,0.001645164,0.00001207881,0.000002134098,0.4594741,0.5182093,0.0005768522],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001008762,0.9818231,0.005313774,0.0006240006,0.007535801,0.00333082,0.00007912479,0.00002273777,0.001169749],"genre_scores_gemma":[0.00003319059,0.8651742,0.1338957,0.0001094411,0.0002496818,0.0001978754,0.00005565345,0.0000388512,0.0002454486],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3450444,"threshold_uncertainty_score":0.9374418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09960630290294531,"score_gpt":0.3774247528075831,"score_spread":0.2778184499046378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}