{"id":"W2036680344","doi":"10.1016/j.molimm.2010.02.014","title":"Novel atypical nucleotide insertions specifically at VH–DH junction generate exceptionally long CDR3H in cattle antibodies","year":2010,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Nucleotide; Gene; Biology; Germline; Genetics; Nucleic acid sequence; Antibody; Locus (genetics); Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002801899,0.000217102,0.000218593,0.0002222288,0.0002366517,0.0004022077,0.0002540803,0.0005152964,0.00134234],"category_scores_gemma":[0.0003257925,0.0002030661,0.000180898,0.0001994425,0.0003046679,0.0001908214,0.0002891394,0.0007313619,0.0004831363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002681741,"about_ca_system_score_gemma":0.0001490709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002693412,"about_ca_topic_score_gemma":0.0006447312,"domain_scores_codex":[0.9998148,0.00004727945,0.00001445199,0.00003432657,0.00003928751,0.00004987432],"domain_scores_gemma":[0.999727,0.0001062176,0.00005878666,0.00003198026,0.00001785934,0.00005815587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001552368,0.00002121999,0.001249811,0.00002324185,0.00001096712,0.0004087801,0.00003162125,0.0001173199,0.9953832,0.0002584278,0.0000468512,0.002293458],"study_design_scores_gemma":[0.00009292136,0.0004861966,0.02625804,0.00001638937,0.00009362729,0.005208149,0.0001098821,0.00209211,0.9593944,0.0004385023,0.00579072,0.00001904187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956318,0.0002395136,0.002974242,0.00004041303,0.000021939,0.00000783189,0.0000772764,0.00003558454,0.0009714962],"genre_scores_gemma":[0.9980929,0.00007406014,0.001195724,0.00004941568,0.00001438863,0.000005798415,0.0001464075,0.00001838986,0.0004028435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00134234,"threshold_uncertainty_score":0.004490554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068707391151155,"score_gpt":0.288425014762908,"score_spread":0.2677379408513965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}