{"id":"W2036682911","doi":"10.1074/jbc.m109.086405","title":"Calcium Activates Nedd4 E3 Ubiquitin Ligases by Releasing the C2 Domain-mediated Auto-inhibition","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto","keywords":"Ubiquitin; NEDD4; Ubiquitin-Protein Ligases; Calcium; Chemistry; Ubiquitin ligase; Cell biology; Ubiquitins; Domain (mathematical analysis); Biophysics; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004581371,0.0002212899,0.0002432696,0.00001525998,0.0001722961,0.00005515642,0.0003270074,0.0004919704,0.0002364119],"category_scores_gemma":[0.001061376,0.0001331171,0.0002278968,0.00009164988,0.0002934688,0.000008205617,0.0001183397,0.0007107242,0.000007468955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002048853,"about_ca_system_score_gemma":0.0001165965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002992141,"about_ca_topic_score_gemma":5.68809e-7,"domain_scores_codex":[0.998677,0.00009564845,0.0004496968,0.0002544771,0.0001971212,0.0003260302],"domain_scores_gemma":[0.9987963,0.0001278351,0.0004401801,0.0002486047,0.0001652457,0.0002218303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001844311,0.00009890052,0.0004883506,0.00001642184,0.0000351898,0.00001913608,0.0000197612,9.500763e-7,0.9938645,0.00001018858,0.004487059,0.0007750622],"study_design_scores_gemma":[0.0004845974,0.0002401141,0.0003726665,0.00002500698,0.00001220194,0.0004080564,0.0001305566,0.000004293264,0.9369989,0.0003376002,0.06080703,0.0001789943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959388,0.0006745948,0.0002858711,0.001483772,0.0001482906,0.00009557422,0.00005916055,0.00001879783,0.001295174],"genre_scores_gemma":[0.9971924,0.0002181518,0.0004699123,0.0006641104,0.001159647,0.000008417716,0.0001295087,0.00001694453,0.0001408585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05686567,"threshold_uncertainty_score":0.542836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01596398154419084,"score_gpt":0.2507450311652806,"score_spread":0.2347810496210897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}