{"id":"W2036694775","doi":"10.1073/pnas.1017087108","title":"Dual interaction of factor H with C3d and glycosaminoglycans in host–nonhost discrimination by complement","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Emil Aaltosen Säätiö; Sigrid Juséliuksen Säätiö; Suomen Kulttuurirahasto; Academy of Finland; Maud Kuistilan Muistosäätiö","keywords":"Factor H; Glycosaminoglycan; Complement system; Alternative complement pathway; Complement (music); Biology; Cell biology; Complement component 2; Chemistry; Biochemistry; Genetics; Gene; Antibody; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002063558,0.0003235432,0.0001724804,0.0001828606,0.0002496896,0.0003577416,0.0003400492,0.0003961663,0.001197604],"category_scores_gemma":[0.0001000814,0.0001399349,0.0001373683,0.0001136486,0.0004482955,0.0002751469,0.0004552039,0.0003554686,0.0002743571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008132128,"about_ca_system_score_gemma":0.0002391238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001367634,"about_ca_topic_score_gemma":0.001810184,"domain_scores_codex":[0.9998413,0.00003501845,0.000006203997,0.00002996901,0.00004965344,0.00003770255],"domain_scores_gemma":[0.9999504,0.000009544499,0.000008547388,0.000003313561,0.000005594432,0.00002259367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002529464,0.00002995558,0.0005066117,0.0000554824,0.00001032329,0.000207378,0.00001615153,0.0001651123,0.9941517,0.001788914,0.0002458768,0.00256961],"study_design_scores_gemma":[0.00006391793,0.00009972579,0.005817564,0.0000116413,0.00001990254,0.0005258597,0.00003962322,0.00528218,0.9800271,0.000919036,0.007177567,0.00001582848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757839,0.00905966,0.007161168,0.0004221204,0.0001089306,0.00002231801,0.0001114773,0.00007438352,0.007256148],"genre_scores_gemma":[0.9943213,0.0009097946,0.002438864,0.00008606848,0.00001529342,0.000006612243,0.00006072555,0.00000581828,0.002155459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001367634,"threshold_uncertainty_score":0.005900323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07217778788557692,"score_gpt":0.3075753946301328,"score_spread":0.2353976067445558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}