{"id":"W2036694775","doi":"10.1073/pnas.1017087108","title":"Dual interaction of factor H with C3d and glycosaminoglycans in host–nonhost discrimination by complement","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Emil Aaltosen Säätiö; Sigrid Juséliuksen Säätiö; Suomen Kulttuurirahasto; Academy of Finland; Maud Kuistilan Muistosäätiö","keywords":"Factor H; Glycosaminoglycan; Complement system; Alternative complement pathway; Complement (music); Biology; Cell biology; Complement component 2; Chemistry; Biochemistry; Genetics; Gene; Antibody; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003286341,0.00006861259,0.0001274395,0.0001397825,0.00006777731,0.000004289874,0.0002252243,0.00003639873,0.00006142195],"category_scores_gemma":[0.00007348407,0.0000439641,0.00002135397,0.0001994953,0.0005916191,0.0002650617,0.00008534978,0.00007088795,6.415026e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002546704,"about_ca_system_score_gemma":0.00001477968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008269584,"about_ca_topic_score_gemma":0.00000313046,"domain_scores_codex":[0.999283,0.00001230286,0.0002889468,0.0001483134,0.0001729723,0.00009447578],"domain_scores_gemma":[0.9994087,0.00007478478,0.0004001974,0.00000635809,0.000102124,0.000007896489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001246753,0.0001646946,0.1948201,0.00009673349,0.00003245897,3.569671e-9,0.001766887,7.181292e-7,0.7892067,0.01305351,0.0004770113,0.0002565143],"study_design_scores_gemma":[0.0003610356,0.0001496448,0.570828,0.0001415244,0.00001154862,0.000005563417,0.00175971,0.00001249494,0.425489,0.001081262,0.0001113687,0.00004890825],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982131,0.0001375808,0.000001592411,0.0002721086,0.00001990623,0.0002144621,0.0001010961,0.000003732318,0.00103646],"genre_scores_gemma":[0.999769,0.00000967807,0.0001409792,0.0000232729,0.000004507227,0.00001102013,0.000001522586,0.000001922637,0.00003806115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3760079,"threshold_uncertainty_score":0.2179845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07217778788557692,"score_gpt":0.3075753946301328,"score_spread":0.2353976067445558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}