{"id":"W2036708534","doi":"10.1117/12.379879","title":"<title>Photofrin mediated PDT in normal rat brain: assessment on apoptosis as a quantitative biological endpoint</title>","year":2000,"lang":"en","type":"article","venue":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute","keywords":"Apoptosis; Propidium iodide; Necrosis; TUNEL assay; Photodynamic therapy; DNA fragmentation; Chemistry; Molecular biology; Programmed cell death; Pathology; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004773871,0.0002279917,0.0003801207,0.0001222676,0.00004351033,0.00003246562,0.0003511971,0.0001524653,0.000723288],"category_scores_gemma":[0.0006362813,0.0001704698,0.0003264075,0.0002973323,0.0002177237,0.0001248865,0.00007629459,0.0003666625,0.00005100021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002420824,"about_ca_system_score_gemma":0.00005594678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005691401,"about_ca_topic_score_gemma":2.316454e-7,"domain_scores_codex":[0.9983684,6.396915e-8,0.0004050029,0.0002970606,0.0005903206,0.0003391898],"domain_scores_gemma":[0.999033,0.0002462514,0.0001119628,0.00004934351,0.0004527761,0.0001067024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004729553,0.0002994291,0.0001701252,0.0001968969,0.0004666198,8.950569e-7,0.0002050318,0.00001429474,0.7277794,0.2536168,0.01579079,0.0009866614],"study_design_scores_gemma":[0.01468529,0.01053293,0.01904526,0.003063446,0.0004614818,0.0001168356,0.003221045,0.06674644,0.5267631,0.006682914,0.3461628,0.002518534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9392882,0.00009282948,0.000002749605,0.003209769,0.0001061759,0.0004937647,0.00004004156,0.00005765263,0.0567088],"genre_scores_gemma":[0.9697882,0.001185086,0.02325936,0.0006908827,0.0003547965,0.0003296588,0.00004721982,0.00008570755,0.004259113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3303719,"threshold_uncertainty_score":0.7919496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871739708257826,"score_gpt":0.2933408344851466,"score_spread":0.2746234374025683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}