{"id":"W2036712345","doi":"10.1210/en.2002-220517","title":"Mechanism for Differential Effect of Protein-Tyrosine Phosphatase 1B on Akt<i>Versus</i>Mitogen-Activated Protein Kinase in 3T3-L1 Adipocytes","year":2002,"lang":"en","type":"article","venue":"Endocrinology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Diego; Hospital for Sick Children; Joslin Diabetes Center","keywords":"Protein kinase B; Internal medicine; Phosphorylation; Endocrinology; Insulin receptor; IRS1; Protein tyrosine phosphatase; Insulin receptor substrate; Tyrosine phosphorylation; IRS2; MAPK/ERK pathway; Biology; Insulin; Protein phosphatase 2; Proto-Oncogene Proteins c-akt; Phosphatase; Chemistry; Cell biology; Insulin resistance; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002999041,0.000492031,0.0004059052,0.0001549657,0.00019966,0.0004507957,0.0002891829,0.0003876285,0.001517021],"category_scores_gemma":[0.0001093783,0.0002191863,0.0005590354,0.0001473108,0.0002844783,0.0003069232,0.00024436,0.001024018,0.0005814351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003735853,"about_ca_system_score_gemma":0.0002218265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006888647,"about_ca_topic_score_gemma":0.0005968641,"domain_scores_codex":[0.9997944,0.00003635603,0.00001933036,0.00004946518,0.00004525971,0.00005513043],"domain_scores_gemma":[0.9999062,0.0000192066,0.00002468225,0.00001404743,0.00001333087,0.00002247853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002390887,0.00003527397,0.0001164092,0.00006672859,0.000006560932,0.00006042165,0.00001343059,0.00003896571,0.9987304,0.0001409231,0.00003177678,0.0005200931],"study_design_scores_gemma":[0.00008937518,0.000345472,0.0062849,0.00001556554,0.00002901615,0.0002411427,0.00005061056,0.0008416476,0.990205,0.0001182673,0.001771258,0.000007716552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868007,0.005452936,0.004288672,0.0004029051,0.0001166083,0.00005349747,0.0008606411,0.0001378957,0.001886299],"genre_scores_gemma":[0.9935034,0.002089987,0.001752549,0.0001596905,0.00001915111,0.00009458906,0.0005869473,0.00003437859,0.001759355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001517021,"threshold_uncertainty_score":0.005074978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01476066252021403,"score_gpt":0.2521011103350677,"score_spread":0.2373404478148537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}