{"id":"W2036723718","doi":"10.1016/j.exphem.2012.06.001","title":"Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines","year":2012,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Cancer Foundation","funders":"National Cancer Institute; National Institutes of Health","keywords":"Cytotoxicity; Cancer research; Epigenetics; Histone deacetylase; Histone deacetylase inhibitor; Biology; Cell growth; Chemistry; Molecular biology; Pharmacology; Histone; Biochemistry; DNA; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000248159,0.000203268,0.000300125,0.00007985363,0.0001027039,0.000007075053,0.0003152975,0.0001842537,0.0000527813],"category_scores_gemma":[0.0001015705,0.0001771903,0.00009966992,0.0001613709,0.0003510223,0.000007368645,0.0002374502,0.00009686354,0.0000293689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000682612,"about_ca_system_score_gemma":0.00005493251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001327292,"about_ca_topic_score_gemma":0.00003702092,"domain_scores_codex":[0.9982853,0.00023552,0.0004398564,0.0003163924,0.0001925944,0.0005303352],"domain_scores_gemma":[0.9991978,0.00006374652,0.0001534553,0.0004284308,0.00003896808,0.0001175882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000116118,0.0005535369,0.003814991,0.00003525172,0.0000204189,0.000009292124,0.0004926571,0.00004231203,0.993936,0.0003343118,0.0005691512,0.00007597604],"study_design_scores_gemma":[0.0006692703,0.0002062361,0.001961697,0.00002008043,0.000005124154,0.000023309,0.000515505,0.0002497276,0.9960303,0.00001057105,0.0001412276,0.0001669865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925106,0.005736456,0.0001019466,0.00003871571,0.0002009547,0.0003073949,0.000009545347,0.00000941581,0.001085015],"genre_scores_gemma":[0.9992113,0.00002941075,0.0002482534,0.00008698207,0.00008740566,0.00008382879,0.00004209927,0.0000314247,0.0001793176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006700721,"threshold_uncertainty_score":0.7225612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010041989929223,"score_gpt":0.3197646947464343,"score_spread":0.2996642748471421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}