{"id":"W2036730592","doi":"10.1111/j.1365-2141.2004.05006.x","title":"Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t‐AML/MDS","year":2004,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"BC Cancer Agency","keywords":"Telomere; Haematopoiesis; Biology; Chemotherapy; Myeloid; Immunology; Stem cell; Myeloid leukemia; Internal medicine; Oncology; Cancer research; Medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008365449,0.000205554,0.0008609407,0.0002984215,0.0001233737,0.00006492157,0.0001416196,0.0001745995,0.00007561518],"category_scores_gemma":[0.0002181033,0.0001684684,0.00008787091,0.0003995715,0.0002156117,0.0002220942,0.00002710614,0.0004464571,8.739686e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005435371,"about_ca_system_score_gemma":0.0002447155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004139166,"about_ca_topic_score_gemma":0.000748608,"domain_scores_codex":[0.9981018,0.0002561471,0.000623238,0.0002743033,0.0004023615,0.0003421599],"domain_scores_gemma":[0.9987487,0.0001842729,0.0004092877,0.0001266797,0.0003122853,0.0002187529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006709661,0.002060164,0.8655531,0.0004545333,0.001375907,0.06938719,0.007547562,0.0000429126,0.02506562,0.001593963,0.0004737836,0.0197356],"study_design_scores_gemma":[0.0102761,0.002265462,0.8204092,0.002432191,0.0003020066,0.1404204,0.001958278,0.00006054715,0.01938233,0.002094583,0.00003625135,0.0003626181],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971016,0.001450173,0.0005431069,0.0004619854,0.00004445441,0.0002954886,0.00005325954,0.00001289627,0.00003701299],"genre_scores_gemma":[0.9954267,0.0003301103,0.002851564,0.001297235,0.00003295927,0.0000103847,0.00001220949,0.00002704031,0.0000118658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07103324,"threshold_uncertainty_score":0.6869943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597535002645169,"score_gpt":0.261623384828452,"score_spread":0.2456480348020004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}