{"id":"W2036748447","doi":"10.2174/138620704773120838","title":"An Efficient Parallel Synthesis of Capsazepine and Capsazepine Analogs","year":2004,"lang":"en","type":"article","venue":"Combinatorial Chemistry & High Throughput Screening","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Capsazepine; Benzazepine; Chemistry; Tetralone; Yield (engineering); Combinatorial chemistry; Stereochemistry; TRPV1; Thermodynamics; Receptor; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002523849,0.0007706368,0.0008064459,0.0004671779,0.0002867693,0.0004138395,0.0004457616,0.0003079717,0.002871743],"category_scores_gemma":[0.0002890399,0.0003303709,0.0004172503,0.0005677014,0.0001953427,0.0003415476,0.0005147752,0.000727895,0.001751586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003817438,"about_ca_system_score_gemma":0.0005870028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004428954,"about_ca_topic_score_gemma":0.001061544,"domain_scores_codex":[0.9996934,0.00003561865,0.0000335733,0.00008312889,0.00009129521,0.00006301968],"domain_scores_gemma":[0.9998764,0.00001415416,0.00002360983,0.00002859687,0.00002128713,0.00003596322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000101974,0.00008080101,0.00008576551,0.0001646235,0.00002794012,0.000242519,0.00003225865,0.001126525,0.981755,0.000753901,0.0003128531,0.0153159],"study_design_scores_gemma":[0.0000676863,0.0007955784,0.0004732763,0.000008137105,0.00004501854,0.0005087714,0.00001265225,0.00180495,0.9840536,0.0002046251,0.01199909,0.00002666413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7354146,0.006680328,0.2097881,0.0005038341,0.0004190475,0.002783169,0.005288275,0.002649093,0.03647359],"genre_scores_gemma":[0.8349072,0.004680515,0.1465748,0.0001805044,0.00006039375,0.0008607213,0.002416336,0.0002079264,0.01011171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002871743,"threshold_uncertainty_score":0.009606957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006605459248874617,"score_gpt":0.235279274180295,"score_spread":0.2286738149314204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}