{"id":"W2036783417","doi":"10.1016/j.taap.2008.07.020","title":"Organochlorines inhibit acetaminophen glucuronidation by redirecting UDP-glucuronic acid towards the d-glucuronate pathway","year":2008,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Health Canada; Centre Hospitalier de l’Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Health Canada","keywords":"Glucuronidation; Glucuronate; Chemistry; Microsome; Glucuronic acid; Acetaminophen; Glucuronosyltransferase; Biochemistry; Pharmacology; Glucuronide; Metabolism; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001581219,0.000620821,0.0002434707,0.0003291897,0.000231489,0.000339316,0.0002404913,0.0003370497,0.001849749],"category_scores_gemma":[0.0004080597,0.0002613029,0.0002833977,0.0002874756,0.0003223554,0.000168196,0.0002652354,0.0004026025,0.0004960449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006085127,"about_ca_system_score_gemma":0.000687267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008995161,"about_ca_topic_score_gemma":0.01060827,"domain_scores_codex":[0.9998543,0.00004091416,0.0000110638,0.0000191395,0.00002740708,0.00004710409],"domain_scores_gemma":[0.9997441,0.00004091468,0.00007282821,0.00003590175,0.00006306166,0.0000432193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000755407,0.00009436646,0.001136668,0.0001038238,0.0000502589,0.0001009619,0.00003842969,0.0002881669,0.987921,0.0002775627,0.0002424549,0.008990907],"study_design_scores_gemma":[0.00002332803,0.0003698744,0.003813754,0.0000086297,0.00002077045,0.00008617574,0.00002398534,0.0004565277,0.9922602,0.00004290915,0.002889159,0.000004737425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836361,0.003054797,0.006424267,0.000332112,0.0000622822,0.00008830838,0.0003132144,0.0001866476,0.005902311],"genre_scores_gemma":[0.9879616,0.002025014,0.003476008,0.0001364961,0.00001481889,0.00003730795,0.0003510553,0.0000320534,0.005965664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008995161,"threshold_uncertainty_score":0.01788563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09858374509708404,"score_gpt":0.351157222367098,"score_spread":0.2525734772700139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}