{"id":"W2036809519","doi":"10.2174/1381612023396681","title":"Basic Pharmacologic Mechanisms Involved in Benzodiazepine Tolerance and Withdrawal","year":2002,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":244,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Benzodiazepine; GABAA receptor; Anxiolytic; Anticonvulsant; Drug tolerance; Receptor; Pharmacology; Diazepam; Sedative; Anti-Anxiety Agents; Anxiety; Medicine; Neuroscience; Psychology; Internal medicine; Psychiatry; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001022052,0.00101614,0.001944522,0.0008070475,0.000320476,0.0001935692,0.001442796,0.0003280896,0.0007088889],"category_scores_gemma":[0.0006594361,0.0008441039,0.0003147588,0.002075761,0.0009355905,0.000428013,0.0006129038,0.003279929,0.0006301146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001828164,"about_ca_system_score_gemma":0.0003020889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.623411e-7,"about_ca_topic_score_gemma":1.682558e-7,"domain_scores_codex":[0.990624,0.003430924,0.001092807,0.002310188,0.0008691869,0.001672885],"domain_scores_gemma":[0.9959572,0.002476184,0.0002997913,0.0004282991,0.00004361154,0.0007949034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009453204,0.0008852783,0.000003780195,0.005105824,0.00001106536,0.001106105,0.00002721229,0.00000802443,0.02385698,0.0004869499,0.001733697,0.9666805],"study_design_scores_gemma":[0.002089182,0.0004326453,0.000001713237,0.002254792,0.0003831052,0.0002382625,0.000001787078,0.006801429,0.0275467,0.0004146683,0.9586943,0.00114145],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001802804,0.9928544,0.0005543218,0.0001562087,0.002317182,0.003562168,0.00006652982,0.0001954739,0.0001134081],"genre_scores_gemma":[0.001370629,0.9962258,0.00006603495,0.001064526,0.0002374675,0.0007646463,0.000003302923,0.0001055876,0.0001619986],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9655391,"threshold_uncertainty_score":0.999401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3710917377046191,"score_gpt":0.4634798362421842,"score_spread":0.09238809853756508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}