{"id":"W2036810108","doi":"10.1042/bj20041125","title":"Structural characterization of <i>Escherichia coli</i> sensor histidine kinase EnvZ: the periplasmic C-terminal core domain is critical for homodimerization","year":2004,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Periplasmic space; Histidine kinase; Biochemistry; Histidine; Osmotic shock; Biology; Escherichia coli; Biophysics; Transmembrane domain; Chemistry; Membrane; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190849,0.0001862439,0.0002023859,0.00003509958,0.0001720262,0.00004133279,0.0002583759,0.0003270388,0.00002420015],"category_scores_gemma":[0.0001210231,0.0001396114,0.0001450201,0.0000962664,0.0003422579,0.000005690908,0.00007547564,0.0001806272,0.000001326324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000293234,"about_ca_system_score_gemma":0.0001395975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002302495,"about_ca_topic_score_gemma":6.831621e-7,"domain_scores_codex":[0.9989239,0.0000282344,0.0003729042,0.0002571654,0.000140892,0.0002768775],"domain_scores_gemma":[0.9992636,0.00001307661,0.0001878567,0.0002193061,0.0002149282,0.0001011956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000330306,0.00004823987,0.00007474251,0.00002698923,0.00003048923,0.000003123719,0.00003767539,0.000002837107,0.9986514,0.0002590196,0.0001629575,0.000372196],"study_design_scores_gemma":[0.0009749557,0.0004740835,0.0009600032,0.00002659879,0.00004411425,0.0002476441,0.00004281298,0.00005111644,0.9920651,0.0005233822,0.004407124,0.000183069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928628,0.0001724517,0.004384801,0.001835504,0.0003338026,0.0002147661,0.000179049,0.00000783774,0.000008950548],"genre_scores_gemma":[0.9938981,0.0001337249,0.004487102,0.0004821087,0.0007003474,0.00001246516,0.0002336225,0.00002408581,0.00002844188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006586328,"threshold_uncertainty_score":0.5693189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167246538684095,"score_gpt":0.2497441299906389,"score_spread":0.2380716646037979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}