{"id":"W2036810108","doi":"10.1042/bj20041125","title":"Structural characterization of <i>Escherichia coli</i> sensor histidine kinase EnvZ: the periplasmic C-terminal core domain is critical for homodimerization","year":2004,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Periplasmic space; Histidine kinase; Biochemistry; Histidine; Osmotic shock; Biology; Escherichia coli; Biophysics; Transmembrane domain; Chemistry; Membrane; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189041,0.000235134,0.0001395106,0.00008265465,0.0001121184,0.0001781004,0.0001757984,0.0001779838,0.0003605962],"category_scores_gemma":[0.0001931826,0.00007623678,0.0001257086,0.0001252892,0.000135596,0.0001478131,0.0001165043,0.0002947407,0.0002184198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002673222,"about_ca_system_score_gemma":0.0001686571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006995958,"about_ca_topic_score_gemma":0.0006363452,"domain_scores_codex":[0.9999398,0.00001087009,0.00000502671,0.00001304701,0.00002118939,0.00001001523],"domain_scores_gemma":[0.9998944,0.00001168484,0.00004187343,0.00000730876,0.00001744369,0.00002740972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005407258,0.00002069443,0.0005076127,0.00002398258,0.00000218496,0.00006150803,0.00002091461,0.000112496,0.998616,0.00004610105,0.0000266983,0.00050777],"study_design_scores_gemma":[0.00002111441,0.0001661193,0.02861881,0.000009564831,0.00001385047,0.0008540169,0.000110839,0.003157813,0.9631402,0.00007319354,0.003823987,0.00001040098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982704,0.0002275714,0.0009359944,0.00005563517,0.000004461971,0.000006271582,0.0002148136,0.0000117461,0.0002732316],"genre_scores_gemma":[0.9959817,0.0002258552,0.001961353,0.00004687683,0.000004844977,0.0000084067,0.0010619,0.0000118914,0.0006971842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006995958,"threshold_uncertainty_score":0.001939595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167246538684095,"score_gpt":0.2497441299906389,"score_spread":0.2380716646037979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}