{"id":"W2036812884","doi":"10.1073/pnas.0910620107","title":"FoxP3 <sup>+</sup> regulatory T cells essentially contribute to peripheral CD8 <sup>+</sup> T-cell tolerance induced by steady-state dendritic cells","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Universität Zürich; Deutsche Forschungsgemeinschaft; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Peripheral tolerance; Antigen-presenting cell; Cell biology; Dendritic cell; FOXP3; T cell; Biology; CD8; Cytotoxic T cell; Immune tolerance; Follicular dendritic cells; Regulatory T cell; IL-2 receptor; Antigen; Immunology; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001553899,0.0003109424,0.0002964315,0.0001823986,0.0001139554,0.00036575,0.0001603492,0.0001801729,0.00245326],"category_scores_gemma":[0.000161127,0.0001271699,0.0001729273,0.00008591729,0.0002959988,0.0002010519,0.0002018482,0.0006788882,0.0007179747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001426013,"about_ca_system_score_gemma":0.0001881819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001891012,"about_ca_topic_score_gemma":0.0001456973,"domain_scores_codex":[0.9998721,0.00001715346,0.000008057918,0.00002823783,0.00002778751,0.00004660011],"domain_scores_gemma":[0.9998186,0.00002684925,0.00003231955,0.00002877292,0.00002893361,0.00006451374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001887961,0.00003317173,0.0006188037,0.00003678789,0.000002711949,0.00008876325,0.00001033857,0.00003613116,0.9942608,0.0001360704,0.00005680095,0.004530826],"study_design_scores_gemma":[0.0001192105,0.0005783925,0.0149703,0.00001892226,0.00005323781,0.001792849,0.00004667975,0.00173927,0.9741544,0.0006555745,0.005864733,0.000006420465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885744,0.002647537,0.004688619,0.0001570789,0.00004126449,0.00002513479,0.0001743393,0.0002736672,0.003418034],"genre_scores_gemma":[0.9948654,0.0006874239,0.001687863,0.00007719135,0.00003329395,0.00001848125,0.0002553322,0.00004138215,0.00233367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00245326,"threshold_uncertainty_score":0.008207023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.014012707937701,"score_gpt":0.2458339032274059,"score_spread":0.2318211952897049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}