{"id":"W2036820990","doi":"10.1016/j.jcf.2014.06.001","title":"Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking","year":2014,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; McGill University","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Cincinnati Children's Hospital Medical Center","keywords":"Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Medicine; Ibuprofen; Regulator; Mutant; Transmembrane protein; Internal medicine; Pharmacology; Cell biology; Genetics; Gene; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001843443,0.0005397993,0.001576082,0.0005957673,0.000256258,0.0001516659,0.0005969051,0.0002622065,0.0004042414],"category_scores_gemma":[0.004282149,0.0004247885,0.0006371923,0.0008283625,0.0004637173,0.0006193008,0.00007269096,0.0009577208,0.00006579698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003499007,"about_ca_system_score_gemma":0.0004721168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002089433,"about_ca_topic_score_gemma":0.00001020606,"domain_scores_codex":[0.9942824,0.0004007992,0.001794216,0.0005527137,0.001973441,0.0009964036],"domain_scores_gemma":[0.9946704,0.001924316,0.0008373446,0.0007910852,0.0009191479,0.0008577268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004972355,0.0003267847,0.0008484656,0.00151381,0.0003203459,0.0001843259,0.0006315531,0.0006475392,0.9713652,0.0004123017,0.002913552,0.01586373],"study_design_scores_gemma":[0.02904472,0.02286376,0.1132825,0.02164857,0.003643803,0.01147754,0.002082764,0.01795012,0.6144781,0.005755456,0.1548341,0.002938588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652495,0.005368483,0.02367014,0.002719827,0.001036734,0.0007963377,0.00008786964,0.0001547134,0.0009164159],"genre_scores_gemma":[0.9179388,0.0001427544,0.08016486,0.0001960398,0.001001479,0.00001683297,0.00001798782,0.000108754,0.000412437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3568871,"threshold_uncertainty_score":0.9998204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01535926136719602,"score_gpt":0.2898002668392427,"score_spread":0.2744410054720467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}