{"id":"W2036831198","doi":"10.1016/j.cell.2007.11.033","title":"Gene Targeting in Embryonic Stem Cells Scores a Knockout in Stockholm","year":2007,"lang":"en","type":"article","venue":"Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Biology; Embryonic stem cell; Gene targeting; Gene knockout; Knockout mouse; Stem cell; Gene; Mutant; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008252129,0.0001580506,0.0001611347,0.0001680825,0.00003418792,0.0000195904,0.0002940374,0.0001834312,0.00002244292],"category_scores_gemma":[0.00001481114,0.000163378,0.00006240804,0.0002289963,0.00004593571,0.000003854127,0.0002104959,0.0002215218,0.00009386699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006398371,"about_ca_system_score_gemma":0.00009222407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006706609,"about_ca_topic_score_gemma":0.0002179021,"domain_scores_codex":[0.998365,0.00008227748,0.0002943385,0.0004398383,0.0001943286,0.0006241626],"domain_scores_gemma":[0.9994522,0.00002912129,0.00005971102,0.0003098933,0.00003889514,0.0001101197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009115998,0.0001006878,0.006325398,0.00004750466,0.000004083151,0.00008521659,0.00006198794,0.000383392,0.9910809,0.000001172132,0.001051701,0.000766834],"study_design_scores_gemma":[0.0007837949,0.0001108677,0.00347369,0.00001896712,0.000001850151,0.000003321449,0.0001243905,0.0001326701,0.9887661,0.000006081699,0.006393545,0.0001847105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925959,0.003277019,0.0002608337,0.00002795652,0.0001234905,0.0002923233,0.000005521167,0.000008912742,0.003408066],"genre_scores_gemma":[0.9942269,0.0002378409,0.0003759882,0.00006489323,0.0001116812,0.00001237084,0.00003107232,0.00003010236,0.004909184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005341845,"threshold_uncertainty_score":0.6662362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241994511173245,"score_gpt":0.2572862760793713,"score_spread":0.2448663309676389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}