{"id":"W2036831198","doi":"10.1016/j.cell.2007.11.033","title":"Gene Targeting in Embryonic Stem Cells Scores a Knockout in Stockholm","year":2007,"lang":"en","type":"article","venue":"Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Biology; Embryonic stem cell; Gene targeting; Gene knockout; Knockout mouse; Stem cell; Gene; Mutant; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003662252,0.001129825,0.0006799601,0.001683899,0.0006760554,0.001214154,0.0007894262,0.0007673549,0.005972028],"category_scores_gemma":[0.0002845888,0.0007085692,0.0006627615,0.0006801601,0.0008199879,0.0006504997,0.001273621,0.001139631,0.002477381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005800994,"about_ca_system_score_gemma":0.0007376197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391904,"about_ca_topic_score_gemma":0.002031775,"domain_scores_codex":[0.9994261,0.00005473416,0.00010417,0.0001559528,0.0001738972,0.00008515044],"domain_scores_gemma":[0.9995854,0.00006733277,0.0001608951,0.00005965882,0.00003339291,0.00009335436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008418337,0.00001636712,0.0001908343,0.00002588917,0.00001135399,0.0001582455,0.00003910636,0.0001408223,0.9974312,0.001033963,0.00004968576,0.0008183275],"study_design_scores_gemma":[0.00002416673,0.00007282772,0.001281177,0.00001312179,0.00005007395,0.0004964059,0.00005991815,0.0003103583,0.9922988,0.0002436216,0.005138565,0.00001111218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9457241,0.001409194,0.02898403,0.0004687041,0.000262112,0.0001057901,0.002127172,0.0008373729,0.02008153],"genre_scores_gemma":[0.9523117,0.001381045,0.009357349,0.0001159736,0.00001604012,0.0001206179,0.001416338,0.0006790194,0.03460186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005972028,"threshold_uncertainty_score":0.0199784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241994511173245,"score_gpt":0.2572862760793713,"score_spread":0.2448663309676389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}