{"id":"W2036853424","doi":"10.1054/ceca.2000.0137","title":"Nucleoplasmic Ca2+loading is regulated by mobilization of perinuclear Ca2+","year":2000,"lang":"en","type":"article","venue":"Cell Calcium","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Medical Research Council; Manitoba Health Research Council","keywords":"Cyclopiazonic acid; Thapsigargin; Ryanodine receptor; Endoplasmic reticulum; Ionomycin; Calcium; Ryanodine receptor 2; Biophysics; Biology; Cell biology; Nucleus; Chemistry; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002573527,0.0003114342,0.0005134964,0.000320272,0.0005045483,0.0007614557,0.0004119174,0.0005215965,0.001765133],"category_scores_gemma":[0.0003958423,0.0002314709,0.0002582794,0.0001865592,0.0004489883,0.0009133561,0.0008837217,0.0005307677,0.0007514886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005783003,"about_ca_system_score_gemma":0.0002717893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104706,"about_ca_topic_score_gemma":0.001704828,"domain_scores_codex":[0.9997813,0.00003015281,0.00001523876,0.00005992068,0.00004149235,0.00007184998],"domain_scores_gemma":[0.9996808,0.00005840847,0.00006035561,0.00003548543,0.00007167119,0.00009339649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003203552,0.00001290959,0.0002067298,0.00004573111,0.000004344615,0.0001100113,0.00004301387,0.00002097963,0.9975478,0.000317717,0.00008958339,0.001280762],"study_design_scores_gemma":[0.0001391842,0.0002287149,0.07763093,0.00004087354,0.00003573431,0.001128435,0.000348896,0.002013071,0.9100006,0.001260583,0.007138946,0.000034119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9424921,0.01711239,0.02746124,0.0008164725,0.0002394498,0.00009619354,0.0006015013,0.0003964862,0.01078431],"genre_scores_gemma":[0.9880058,0.002429628,0.004990444,0.0001463159,0.00007207787,0.00009797562,0.0003506485,0.00008118452,0.003825932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001765133,"threshold_uncertainty_score":0.005904973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00782389856747025,"score_gpt":0.2339919153856907,"score_spread":0.2261680168182204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}