{"id":"W2036867599","doi":"10.1007/s10495-005-6066-7","title":"Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells","year":2005,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Trace Elements in Health","field":"Nursing","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Apoptosis; Reactive oxygen species; Mitochondrion; Annexin; Chemistry; Cell biology; Programmed cell death; Cancer cell; Copper deficiency; Transactivation; Intracellular; Biology; Molecular biology; Cancer research; Copper; Biochemistry; Transcription factor; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004673869,0.0001530338,0.0002837038,0.0002816528,0.00004657025,0.00001807082,0.00009543843,0.00008377163,0.00006044603],"category_scores_gemma":[0.00006182593,0.0001573917,0.00001987967,0.0002769461,0.00007911761,0.0001687017,0.00006550461,0.000168898,0.000008499819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429759,"about_ca_system_score_gemma":0.00004094865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002691093,"about_ca_topic_score_gemma":0.002953696,"domain_scores_codex":[0.9985953,0.0001910796,0.0003508983,0.0003229512,0.0001858968,0.000353849],"domain_scores_gemma":[0.9992912,0.000283916,0.00008719715,0.000190434,0.0000365509,0.0001106737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004236184,0.0001937126,0.07919738,0.00005036889,0.00001501366,6.577375e-7,0.01030646,0.0001270065,0.8719259,0.00003575512,0.0003836446,0.03352792],"study_design_scores_gemma":[0.0009375238,0.0001331978,0.6616685,0.0001477399,0.00001357018,0.00000253658,0.001376699,0.00004686896,0.3332925,0.00004510512,0.002186248,0.0001494044],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916379,0.0002299756,7.412171e-7,0.007199049,0.0001232663,0.0004340633,0.0001472147,0.00001510437,0.0002127196],"genre_scores_gemma":[0.9982207,0.00009282383,0.001022579,0.0004219136,0.00009554558,0.0000386057,0.000001504564,0.00002514754,0.00008112686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5824712,"threshold_uncertainty_score":0.6418245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026201748786188,"score_gpt":0.2751822826602134,"score_spread":0.2649202651723515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}