{"id":"W2036959160","doi":"10.1172/jci38420","title":"Hoofbeats, zebras, and insights into insulin resistance","year":2009,"lang":"en","type":"letter","venue":"Journal of Clinical Investigation","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Robarts Research Institute; U.S. Public Health Service; National Institutes of Health; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Heart and Stroke Foundation of Canada; Pfizer","keywords":"AKT2; Phenotype; Biology; Insulin resistance; Insulin receptor; Gluconeogenesis; Genetics; Serine; Insulin; Gene; Signal transduction; Phosphorylation; PI3K/AKT/mTOR pathway; Endocrinology; AKT1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00109488,0.0006214467,0.000726148,0.0006256409,0.001309508,0.001772425,0.0008557873,0.01296623,0.003047726],"category_scores_gemma":[0.005438455,0.0003754843,0.0004672917,0.0002997341,0.002053392,0.001776058,0.0005975591,0.01574323,0.001767239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001618917,"about_ca_system_score_gemma":0.0006285288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001100842,"about_ca_topic_score_gemma":0.002090972,"domain_scores_codex":[0.9991867,0.0002972819,0.00008738262,0.0001311841,0.0002012375,0.00009622086],"domain_scores_gemma":[0.99827,0.001003755,0.00009680316,0.00009938925,0.0002617435,0.0002683807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002594116,0.0001209375,0.002537244,0.0001111804,0.00004242239,0.01140037,0.0001553349,0.0001275923,0.001021444,0.009941859,0.9393368,0.03494557],"study_design_scores_gemma":[0.000600738,0.0002383094,0.004464583,0.0004131119,0.00007837413,0.02690536,0.0004803961,0.001451204,0.001635214,0.03801718,0.9256421,0.00007326468],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001882145,0.01103705,0.0002455062,0.9584583,0.02380759,0.00001168605,0.00002367728,0.00004521753,0.004488757],"genre_scores_gemma":[0.03778668,0.01668048,0.0006593252,0.7993692,0.132514,0.00003646803,0.00003223939,0.00003508047,0.0128865],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01296623,"threshold_uncertainty_score":0.01174617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03266140672667361,"score_gpt":0.3235807835417386,"score_spread":0.290919376815065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}