{"id":"W2036978143","doi":"10.1016/s1046-2023(03)00084-7","title":"Expression, purification, and analysis of MOZ and MORF histone acetyltransferases","year":2003,"lang":"en","type":"article","venue":"Methods","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"PCAF; Histone Acetyltransferases; Chromatin; Histone; Acetylation; Histone acetyltransferase; Bromodomain; Biology; Chemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003845083,0.0005129006,0.0005264311,0.0006051142,0.0006512993,0.0007558949,0.0005856398,0.0003281203,0.001362857],"category_scores_gemma":[0.0004646358,0.0004548446,0.0004716037,0.0006451962,0.000361725,0.0003065589,0.0003630524,0.001507488,0.001356583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001234225,"about_ca_system_score_gemma":0.0008073028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004913888,"about_ca_topic_score_gemma":0.008913751,"domain_scores_codex":[0.9995788,0.00002929066,0.00005031568,0.00007649358,0.0001739979,0.00009122521],"domain_scores_gemma":[0.9997095,0.0000540406,0.00004961765,0.0000648833,0.00006178374,0.00006024292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001527007,0.00004283233,0.0004459874,0.00009877809,0.00001619446,0.0000367665,0.00003571117,0.000157508,0.9943234,0.0007498401,0.0002840644,0.003656338],"study_design_scores_gemma":[0.00001509964,0.0000393091,0.004433909,0.000007629827,0.00001559922,0.0001349867,0.00002041289,0.001035142,0.9765836,0.0001311801,0.01757456,0.000008519419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7355613,0.007642279,0.2306962,0.001273923,0.0003475201,0.0006403517,0.01560814,0.001750186,0.00648022],"genre_scores_gemma":[0.7219795,0.008788059,0.1868676,0.0004023495,0.0001332095,0.001133878,0.0408312,0.001025002,0.0388392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004913888,"threshold_uncertainty_score":0.009770572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808097730546628,"score_gpt":0.3500703981048304,"score_spread":0.3319894207993642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}