{"id":"W2036980334","doi":"10.1371/journal.pone.0019756","title":"Mechanical Tension Increases CCN2/CTGF Expression and Proliferation in Gingival Fibroblasts via a TGFβ-Dependent Mechanism","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"CTGF; Connective tissue; Wound healing; Myofibroblast; Cell biology; Transforming growth factor; Fibroblast; Growth factor; Chemistry; Type I collagen; Fibrosis; Cell growth; Cancer research; Receptor; Pathology; Biology; Molecular biology; Cell culture; Endocrinology; Medicine; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002272785,0.0001431681,0.0001706926,0.00008853359,0.00006018695,0.00001790342,0.0001128527,0.0001509309,0.00007586541],"category_scores_gemma":[0.000292016,0.0001356995,0.00002670824,0.00006307283,0.00003009865,0.00001164481,0.0002964805,0.000141641,0.00001277333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002512443,"about_ca_system_score_gemma":0.00003715915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000134416,"about_ca_topic_score_gemma":0.0001301366,"domain_scores_codex":[0.9987089,0.0001444853,0.0001788412,0.0004270004,0.0002882718,0.0002524996],"domain_scores_gemma":[0.9994575,0.00002198097,0.0000471465,0.0002482274,0.0001035709,0.0001216144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003294328,0.0007016685,0.003976782,0.00004547702,0.00003015926,0.00001500678,0.00007616918,1.893777e-7,0.9944149,0.0001210171,0.00001092074,0.0002782517],"study_design_scores_gemma":[0.0007045855,0.0005997913,0.005264279,0.0001213295,0.00001561203,0.00001173769,0.00002975431,0.000447929,0.9915118,0.001128555,0.000005679892,0.0001589961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979727,0.0001431791,0.001228916,0.00004442689,0.00001433842,0.0004625899,0.00000952797,0.00001982695,0.0001044418],"genre_scores_gemma":[0.9976227,0.0000597058,0.001983405,0.00003671409,0.00007948976,0.00007193685,0.00003828411,0.00002430675,0.00008351084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002903174,"threshold_uncertainty_score":0.5533665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0484643569504047,"score_gpt":0.2490488656625329,"score_spread":0.2005845087121282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}