{"id":"W2036989655","doi":"10.3899/jrheum.090194","title":"Interleukin 6 (IL-6) Deficiency Delays Lupus Nephritis in MRL-<i>Fas<sup>lpr</sup></i>Mice: The IL-6 Pathway as a New Therapeutic Target in Treatment of Autoimmune Kidney Disease in Systemic Lupus Erythematosus","year":2009,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft","keywords":"Medicine; Lupus nephritis; Terminal deoxynucleotidyl transferase; Kidney; Immunology; Systemic lupus erythematosus; Cytokine; Nephritis; TUNEL assay; Interleukin 10; Interleukin; Internal medicine; Endocrinology; Immunohistochemistry; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003691023,0.0008546257,0.0005999434,0.0005684423,0.0001663185,0.0004413448,0.0003747811,0.0005929332,0.001490507],"category_scores_gemma":[0.0002037224,0.0002820728,0.0003564424,0.0001915027,0.0004219321,0.0005220596,0.0002033934,0.001658094,0.0007363871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000254168,"about_ca_system_score_gemma":0.0002495944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002228662,"about_ca_topic_score_gemma":0.0004144054,"domain_scores_codex":[0.999605,0.00007886588,0.0000780792,0.00008274695,0.00008561047,0.00006978719],"domain_scores_gemma":[0.999253,0.00005520051,0.0003501349,0.00005356088,0.00006029493,0.0002279295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005373043,0.000123072,0.0001838059,0.0000426844,0.000006116576,0.00004460499,0.00001299915,0.00004759919,0.9982078,0.00004117901,0.00002152243,0.0007314128],"study_design_scores_gemma":[0.0002020422,0.002990824,0.004101865,0.00002234256,0.0000491231,0.0007258453,0.00003757365,0.0009955429,0.989281,0.00004881474,0.001533759,0.00001121526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931254,0.001879041,0.003133937,0.0001896392,0.00005653392,0.00004533324,0.0005751721,0.0002847828,0.0007099408],"genre_scores_gemma":[0.9863833,0.001590234,0.006833965,0.0001399766,0.0000701009,0.00009368896,0.000918102,0.0001150709,0.003855585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001490507,"threshold_uncertainty_score":0.004986227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01580100112925743,"score_gpt":0.2737276332269183,"score_spread":0.2579266320976609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}