{"id":"W2037004316","doi":"10.1073/pnas.0509870103","title":"Polyvalent inhibitors of anthrax toxin that target host receptors","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Anthrax toxin; Receptor; Toxin; Biology; Microbiology; Antimicrobial; Phage display; Bacillus anthracis; Pathogen; In vivo; Peptide; Computational biology; Bacteria; Recombinant DNA; Biochemistry; Fusion protein; Biotechnology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007699933,0.00007205929,0.0001113201,0.00007231886,0.00008624599,0.00001016947,0.0004673106,0.00009788674,0.00002422384],"category_scores_gemma":[0.0001896442,0.00004858758,0.00008076442,0.0002889958,0.000819791,0.00001604639,0.0001450601,0.00006745862,5.012695e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001002562,"about_ca_system_score_gemma":0.00003782177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002148703,"about_ca_topic_score_gemma":1.82967e-7,"domain_scores_codex":[0.9987229,0.000005975303,0.0002323437,0.0001867556,0.0007112444,0.0001408578],"domain_scores_gemma":[0.9994727,0.00001691685,0.0002577408,0.000009268515,0.0002189272,0.00002442652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002549636,0.00003992623,0.01494118,0.00002999314,0.000006382425,1.114014e-9,0.00001483887,0.000009821358,0.980279,0.002220809,0.002282281,0.0001502697],"study_design_scores_gemma":[0.0001189191,0.00007754392,0.03736668,0.00002767718,0.00000257465,0.000001181873,0.00004440023,0.00002039799,0.957666,0.002108305,0.002512874,0.00005344716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930983,0.0003334419,0.000001302798,0.0008510372,0.00004642851,0.000109928,0.00002983695,0.000001881333,0.005527854],"genre_scores_gemma":[0.9988762,0.00008617783,0.000501861,0.00003927745,0.0001734871,0.000003490131,7.635865e-7,0.000003583973,0.0003151683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.022613,"threshold_uncertainty_score":0.3020554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02525119548160335,"score_gpt":0.2879444499423277,"score_spread":0.2626932544607243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}