{"id":"W2037013087","doi":"10.1371/journal.pone.0003652","title":"A miRNA Signature of Prion Induced Neurodegeneration","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":246,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Science Centre for Human and Animal Health; University of Manitoba; Public Health Agency of Canada","funders":"Public Health Agency of Canada","keywords":"Neurodegeneration; microRNA; Biology; DNA microarray; Gene expression; Scrapie; Gene expression profiling; Gene; Regulation of gene expression; Computational biology; Non-coding RNA; Cell biology; Genetics; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005286266,0.00004974608,0.00007453904,0.00002533848,0.00004163354,0.000003153692,0.00007163956,0.00007671899,0.000008575747],"category_scores_gemma":[0.00008993845,0.00004676711,0.00002609569,0.00005440997,0.00001930479,0.000002090994,0.00003139849,0.00007343177,0.000003927492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003668903,"about_ca_system_score_gemma":0.00004168229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001154956,"about_ca_topic_score_gemma":0.000006735846,"domain_scores_codex":[0.9994919,0.00003200258,0.00008627151,0.0001260992,0.0001588221,0.0001048555],"domain_scores_gemma":[0.9996819,0.00000365766,0.00003190945,0.0001553054,0.00008564523,0.00004155776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000428936,0.0002089759,0.001443362,0.00001639803,0.00002992801,0.000002331146,0.00002271774,0.000004556684,0.9977874,0.000009187474,0.0001963813,0.0002358366],"study_design_scores_gemma":[0.0002050533,0.0002838623,0.004078759,0.00001222643,0.000005654069,0.000002212196,0.000003595669,0.0001986167,0.9951018,0.000004237829,0.00005575068,0.00004823953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991874,0.0002664618,0.00006664338,0.0001054452,0.000009122547,0.0001088909,0.000002786158,0.000004962775,0.000248343],"genre_scores_gemma":[0.9979464,0.0002506781,0.0006464011,0.00007672644,0.0001037789,0.000006743218,0.0000381774,0.000008282203,0.0009227747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002685639,"threshold_uncertainty_score":0.1907107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04866080767436587,"score_gpt":0.2449580014435406,"score_spread":0.1962971937691747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}