{"id":"W2037068483","doi":"10.1021/jm049864b","title":"Novel Azapeptide Inhibitors of Hepatitis C Virus Serine Protease","year":2004,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; Proteases; Serine protease; Protease; Serine; Serine Proteinase Inhibitors; Enzyme; Biochemistry; Stereochemistry; Enzyme inhibitor; NS3; Active site; Cysteine; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000142432,0.0004101115,0.0003923465,0.000189921,0.0001217823,0.0002115081,0.0003269145,0.0002355292,0.0009807308],"category_scores_gemma":[0.000101805,0.0001288874,0.0001549772,0.0001119288,0.0001455819,0.0002644831,0.0001522125,0.0005313582,0.0003490136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002310908,"about_ca_system_score_gemma":0.0001338485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002494241,"about_ca_topic_score_gemma":0.0008157045,"domain_scores_codex":[0.9999264,0.00001134003,0.000005551271,0.00001391687,0.00002398091,0.00001871211],"domain_scores_gemma":[0.999962,0.00000655488,0.000009113177,0.000002554361,0.000006838688,0.00001304098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005136327,0.0001755768,0.0002419041,0.0002123347,0.00002831883,0.0004386915,0.00003985779,0.001030702,0.9681221,0.001022851,0.0004041762,0.02776977],"study_design_scores_gemma":[0.0004174226,0.003608165,0.002117748,0.00002436189,0.00005455921,0.001861608,0.00001738255,0.00438598,0.9608446,0.0002985141,0.0263426,0.00002712943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9252905,0.03802741,0.02028338,0.0004039837,0.0002393632,0.000424605,0.0006201782,0.00026521,0.01444529],"genre_scores_gemma":[0.9529047,0.0217383,0.01375313,0.0002934103,0.0001104996,0.0002128953,0.0009190806,0.00002125098,0.01004667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009807308,"threshold_uncertainty_score":0.003280878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01992339348987408,"score_gpt":0.3031155015295238,"score_spread":0.2831921080396497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}