{"id":"W2037070180","doi":"10.1523/jneurosci.5166-10.2011","title":"SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Wakefulness; Neuroscience; Basal forebrain; Biology; Forebrain; Neurodegeneration; Brainstem; Cholinergic neuron; Lipofuscin; Cholinergic; Internal medicine; Medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008945267,0.0002277094,0.0002126719,0.000184108,0.0001778525,0.0002101352,0.0001587987,0.0002148222,0.0007730474],"category_scores_gemma":[0.00006736092,0.0001020578,0.0003773443,0.00009783736,0.0002400965,0.0001551826,0.0001964971,0.000387343,0.0002156063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002758779,"about_ca_system_score_gemma":0.0001777046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000723958,"about_ca_topic_score_gemma":0.001991407,"domain_scores_codex":[0.9999372,0.0000073659,0.000007748975,0.00001888712,0.00001272525,0.00001602868],"domain_scores_gemma":[0.9999187,0.000004220631,0.00002825229,0.000008683081,0.00001401446,0.00002609449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001606131,0.00001845302,0.0006871623,0.00004221409,0.00001010147,0.00006646189,0.00003475876,0.00003409017,0.9970379,0.0001535954,0.00005784991,0.001696873],"study_design_scores_gemma":[0.00004229979,0.0007262235,0.1249227,0.00001884755,0.00006834484,0.0006126886,0.0001710766,0.0007573086,0.8666254,0.0004060348,0.005631263,0.00001785907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916338,0.004062329,0.002183059,0.0001143728,0.00004551227,0.00001422443,0.0004261769,0.0001003819,0.001420138],"genre_scores_gemma":[0.9960749,0.001074017,0.0006182708,0.00004472997,0.000006310617,0.00001921306,0.0003224442,0.00001167433,0.001828448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007730474,"threshold_uncertainty_score":0.002586067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04678572785999451,"score_gpt":0.2750315745317887,"score_spread":0.2282458466717942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}