{"id":"W2037093159","doi":"10.1074/jbc.m707650200","title":"Aldo-keto Reductase Family 1 B10 Affects Fatty Acid Synthesis by Regulating the Stability of Acetyl-CoA Carboxylase-α in Breast Cancer Cells","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health","keywords":"Immunoprecipitation; Biochemistry; Biology; Reductase; Pyruvate carboxylase; Fatty acid synthesis; Cytoplasm; Intracellular; Fatty acid; Cell growth; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001063956,0.0002326377,0.0004062702,0.0000203692,0.00005358173,0.00001145429,0.000362474,0.0003425957,0.00007565358],"category_scores_gemma":[0.000253673,0.0001444231,0.0002313538,0.000163273,0.0003026597,0.000006995913,0.0001293294,0.0003582149,4.600772e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007095758,"about_ca_system_score_gemma":0.0001249605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003596891,"about_ca_topic_score_gemma":0.000004508486,"domain_scores_codex":[0.9983947,0.0001066076,0.0006203375,0.0002952188,0.0002225055,0.0003605854],"domain_scores_gemma":[0.9986982,0.0001331089,0.000538606,0.0003239126,0.0001549034,0.0001512452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004871827,0.0002015798,0.006271289,0.00005748454,0.00007855668,0.00001864499,0.00002139725,0.00001310367,0.9904872,6.661905e-7,0.0008570681,0.001505882],"study_design_scores_gemma":[0.0004028174,0.0001092806,0.006806115,0.0000726775,0.00003332164,0.0001205078,0.0003943533,0.000004225896,0.9914268,0.000013072,0.0004489475,0.0001678585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959908,0.00299374,0.00004397595,0.0003072124,0.00008059688,0.00009900751,0.0001839152,0.000004135461,0.0002966182],"genre_scores_gemma":[0.9983808,0.0008408007,0.0002429441,0.00008945061,0.0003932218,0.000005545623,0.00002150387,0.00001313534,0.00001255664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002390043,"threshold_uncertainty_score":0.5889403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01391220942205493,"score_gpt":0.250764803248957,"score_spread":0.2368525938269021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}