{"id":"W2037145446","doi":"10.1371/journal.pone.0026622","title":"Sleep Loss Reduces the DNA-Binding of BMAL1, CLOCK, and NPAS2 to Specific Clock Genes in the Mouse Cerebral Cortex","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal; Canadian Sleep & Circadian Network","funders":"Université de Lausanne; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"PER1; PER2; CLOCK; Chromatin immunoprecipitation; Biology; Circadian clock; Sleep deprivation; Cell biology; Genetics; Circadian rhythm; Gene expression; Gene; Endocrinology; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002474307,0.0001343173,0.0001966208,0.00009748298,0.0001361782,0.000040805,0.0003779258,0.00005473259,0.00007686485],"category_scores_gemma":[0.0001065167,0.00008746563,0.00003853261,0.0003321109,0.0001968609,0.0001074741,0.00009408609,0.0001800974,0.00007223482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001752994,"about_ca_system_score_gemma":0.00001591964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002688014,"about_ca_topic_score_gemma":0.00002115817,"domain_scores_codex":[0.9986835,0.0001254767,0.000240278,0.0003311762,0.0003118009,0.0003077505],"domain_scores_gemma":[0.9992492,0.0001689767,0.00008853033,0.0003911553,0.00002152623,0.00008064024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006331565,0.0004631622,0.0171787,0.00002641377,0.00001268161,0.0000331146,0.008570554,0.000001336037,0.9563268,0.01641971,0.0001075981,0.0007966582],"study_design_scores_gemma":[0.0002409246,0.00009187317,0.04360909,0.00003552534,0.00001885289,0.00002335644,0.0006083121,0.00004063222,0.954569,0.000107543,0.0005316031,0.0001232438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965716,0.0004903532,0.000002366316,0.0005050168,0.00007330941,0.0004458721,0.00002370172,0.00002323577,0.001864522],"genre_scores_gemma":[0.998705,0.0002565136,0.000147122,0.0002775424,0.0001173703,0.00002942994,7.897123e-7,0.00001897186,0.0004472375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02643039,"threshold_uncertainty_score":0.3566745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09103556681064462,"score_gpt":0.2334628626868854,"score_spread":0.1424272958762408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}