{"id":"W2037147607","doi":"10.1016/j.jmb.2005.11.028","title":"Involvement of Polynucleotide Kinase in a Poly(ADP-ribose) Polymerase-1-dependent DNA Double-strand Breaks Rejoining Pathway","year":2005,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Cancer Foundation","funders":"Commissariat à l'Énergie Atomique et aux Énergies Alternatives; Ligue Contre le Cancer; Electricité de France; Fondation pour la Recherche Médicale","keywords":"DNA ligase; DNA repair; Molecular biology; Biology; DNA; Polymerase; DNA polymerase; DNA polymerase mu; Poly ADP ribose polymerase; Sticky and blunt ends; DNA damage; Recombinant DNA; DNA clamp; Biochemistry; Circular bacterial chromosome; Gene; RNA; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004283642,0.0005792335,0.0002992198,0.0003327261,0.0004473836,0.0005974367,0.0003912311,0.0009959827,0.003365766],"category_scores_gemma":[0.0004330806,0.0003940522,0.0004477083,0.00009540746,0.000347691,0.0008822355,0.0002577529,0.001319414,0.00122725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000594873,"about_ca_system_score_gemma":0.0004558255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003505459,"about_ca_topic_score_gemma":0.000293868,"domain_scores_codex":[0.9997844,0.00004200537,0.00001822351,0.00006160755,0.00004904962,0.00004463821],"domain_scores_gemma":[0.9996842,0.00009011587,0.00006382303,0.00004977264,0.000049569,0.00006245312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008166055,0.0001487158,0.000552455,0.0002279535,0.00002338067,0.0005913184,0.00004210391,0.0006490894,0.9895069,0.001857162,0.0002087558,0.005375537],"study_design_scores_gemma":[0.00009009845,0.0004888966,0.005134184,0.00002703593,0.00003092867,0.00117567,0.00004054172,0.003644187,0.9845294,0.0009525932,0.003871357,0.00001507276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9396448,0.01197272,0.03577499,0.00223572,0.000436793,0.0002488423,0.000750867,0.0004878083,0.008447556],"genre_scores_gemma":[0.9815749,0.002422821,0.009681608,0.0001554192,0.00005034705,0.00006698241,0.000570807,0.00002217042,0.005454878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003365766,"threshold_uncertainty_score":0.01125956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02073080951036261,"score_gpt":0.3104441611270539,"score_spread":0.2897133516166913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}