{"id":"W2037185271","doi":"10.1038/sj.onc.1208521","title":"Stimulation of the Ras-MAPK pathway leads to independent phosphorylation of histone H3 on serine 10 and 28","year":2005,"lang":"en","type":"article","venue":"Oncogene","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Cancer Institute; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Histone H3; Phosphorylation; Serine; Biology; Acetylation; Histone; MAPK/ERK pathway; Kinase; Molecular biology; Protein phosphorylation; Cell biology; Protein kinase A; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009749063,0.00007770816,0.00009578554,0.00002065487,0.00002715742,0.000003295131,0.00008558665,0.00007311542,0.00002833364],"category_scores_gemma":[0.00002328374,0.0000645644,0.00003873962,0.00004796787,0.00002552277,0.000001567088,0.00006011622,0.00002987236,0.000003476653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002716548,"about_ca_system_score_gemma":0.00003596847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009947586,"about_ca_topic_score_gemma":0.00006445363,"domain_scores_codex":[0.9994853,0.00001726611,0.000176565,0.000142835,0.0001016405,0.00007635837],"domain_scores_gemma":[0.9995641,0.000005806299,0.0001080509,0.0002295941,0.00006113048,0.00003137469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006538106,0.0000530147,0.001475451,0.00001104886,0.00001094532,9.58031e-8,0.00005250594,0.009847188,0.9795008,0.0000741383,0.0001120835,0.008797371],"study_design_scores_gemma":[0.0004096427,0.0002680576,0.017689,0.00001210949,0.000009936414,0.0000020302,0.00001139755,0.001113548,0.9732112,0.00002244763,0.007172975,0.00007762138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983627,0.0002062638,0.0002923008,0.0001324739,0.00005540574,0.0001405057,0.00002515204,0.000002106617,0.000783069],"genre_scores_gemma":[0.997956,0.00003890439,0.0008273459,0.00007565426,0.0000582117,0.000004137592,0.00003883818,0.00001073484,0.0009901189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01621355,"threshold_uncertainty_score":0.263286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006342380887295346,"score_gpt":0.2475827646697313,"score_spread":0.241240383782436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}