{"id":"W2037193718","doi":"10.1081/dmr-55227","title":"Oxidative Stress Mediated Idiosyncratic Drug Toxicity","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism Reviews","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Oxidative stress; Pharmacology; Biochemistry; Inflammation; Toxicity; Glutathione peroxidase; Drug metabolism; Glutathione; Hepatocyte; Superoxide dismutase; Metabolism; Biology; Enzyme; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.003868545,0.0006004057,0.00119204,0.0002390136,0.0005712258,0.00006151995,0.0006336453,0.0003946788,0.003124065],"category_scores_gemma":[0.0006974055,0.0005171997,0.0004012685,0.0007600529,0.0002073394,0.0006291684,0.0001492786,0.001836322,0.004752288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001358218,"about_ca_system_score_gemma":0.0001112512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007293293,"about_ca_topic_score_gemma":0.0003581957,"domain_scores_codex":[0.9933583,0.003558341,0.001194288,0.0007081116,0.000357992,0.0008229876],"domain_scores_gemma":[0.9976605,0.0005103821,0.0006074148,0.0005662911,0.0001556364,0.000499754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003061518,0.002036628,0.001389185,0.0008046936,0.0005818085,0.00004048572,0.01231452,0.0004073405,0.2407666,0.004669632,0.08395769,0.6527253],"study_design_scores_gemma":[0.0009065314,0.0000111825,0.0003638666,0.00006624945,0.0002468799,0.000009576296,0.0001015748,0.0008992694,0.2297945,0.0002909701,0.7668517,0.0004577773],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8806925,0.07670149,0.0005357803,0.007010504,0.004681431,0.004829268,0.0004036197,0.0005959537,0.0245494],"genre_scores_gemma":[0.941179,0.03661425,0.001518783,0.01059631,0.002697016,0.0008211252,0.0001808892,0.00009087412,0.006301799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6828939,"threshold_uncertainty_score":0.999728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.102215871689094,"score_gpt":0.4038505234028904,"score_spread":0.3016346517137964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}