{"id":"W2037206324","doi":"10.1038/sj.gt.3302907","title":"Plasmid-based gene therapy of diabetes mellitus","year":2007,"lang":"en","type":"review","venue":"Gene Therapy","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Krembil Foundation","keywords":"Genetic enhancement; Immune system; Biology; Immunology; Glucose homeostasis; Islet; Antigen; Immune tolerance; DNA vaccination; Gene delivery; Diabetes mellitus; Endocrinology; Gene; Insulin resistance; Genetics; Immunization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000539135,0.0009149702,0.001337883,0.00160779,0.0002220578,0.0007989838,0.00114702,0.001031946,0.001989609],"category_scores_gemma":[0.0003802066,0.0002911896,0.0003876821,0.001646949,0.0006162687,0.0009011548,0.0004425508,0.001884226,0.002002764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000612519,"about_ca_system_score_gemma":0.0005056175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007060358,"about_ca_topic_score_gemma":0.001181419,"domain_scores_codex":[0.9998595,0.0000205307,0.00001396722,0.00002272086,0.00006771996,0.00001564116],"domain_scores_gemma":[0.9998629,0.00006813472,0.00001916879,0.000007142953,0.00003040448,0.00001218053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001053705,0.000149048,0.00009169983,0.006280124,0.00006780493,0.0003911878,0.00004672603,0.0005445695,0.0124057,0.006841068,0.02846976,0.9446069],"study_design_scores_gemma":[0.00004795229,0.0001057731,0.0003840879,0.0009472431,0.00009131885,0.001562591,0.00002832703,0.0001835151,0.004268128,0.002423227,0.9899372,0.0000206024],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003542586,0.9943331,0.002078283,0.0002947233,0.0005605033,0.00001389159,0.00002772567,0.00003531008,0.002302217],"genre_scores_gemma":[0.001711566,0.9944934,0.001262829,0.00023432,0.0001829296,0.00001833134,0.00005612417,0.000005868133,0.002034627],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001989609,"threshold_uncertainty_score":0.006655872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05274247453423182,"score_gpt":0.3264402536591247,"score_spread":0.2736977791248929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}