{"id":"W2037218966","doi":"10.1038/nbt.2769","title":"Reply to Rational drug repositioning by medical genetics","year":2013,"lang":"en","type":"letter","venue":"Nature Biotechnology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital; McGill University and Génome Québec Innovation Centre","funders":"","keywords":"Drug repositioning; Medical genetics; Drug; Computational biology; Drug discovery; Genetics; Medicine; Pharmacology; Biology; Bioinformatics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005906909,0.0009297458,0.002092936,0.0008587263,0.004581138,0.005203729,0.002445582,0.1190612,0.004714322],"category_scores_gemma":[0.03922303,0.001311597,0.001769311,0.000868837,0.007155525,0.004656737,0.003068635,0.08381192,0.003845989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0074056,"about_ca_system_score_gemma":0.006091378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006376691,"about_ca_topic_score_gemma":0.01044901,"domain_scores_codex":[0.9950094,0.001292155,0.0005424893,0.0006504234,0.0016074,0.0008981331],"domain_scores_gemma":[0.985339,0.009061384,0.0009131481,0.0005029578,0.001784779,0.002398614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007487896,0.00003243894,0.0004667529,0.00003733065,0.00003514091,0.001263938,0.00009012801,0.0001178836,0.0001651514,0.005965134,0.9852019,0.006549397],"study_design_scores_gemma":[0.0004977289,0.0001447852,0.001522732,0.0003746667,0.0001250357,0.002497341,0.0004110199,0.001483248,0.0006273057,0.04730549,0.9448204,0.0001901486],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001724543,0.0008170948,0.00009169264,0.9893476,0.00866666,0.000005339794,0.00002472265,0.00001380779,0.0008606508],"genre_scores_gemma":[0.002384376,0.0005370468,0.0001567687,0.97584,0.01896629,0.00001959154,0.00001245604,0.00001055864,0.002072796],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1190612,"threshold_uncertainty_score":0.05373162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00382202988788597,"score_gpt":0.2445973872030485,"score_spread":0.2407753573151626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}