{"id":"W2037219931","doi":"10.1038/cdd.2015.38","title":"Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Fonds National de la Recherche Luxembourg","keywords":"Oxidative stress; Isocitrate dehydrogenase; Reactive oxygen species; IDH1; Lipopolysaccharide; Tumor necrosis factor alpha; Oxidative phosphorylation; Intracellular; Chemistry; Inflammation; Antioxidant; Biology; Biochemistry; Endocrinology; Immunology; Enzyme; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442838,0.0001989737,0.0001449437,0.00002339005,0.0001493487,0.00008996519,0.0001358129,0.0001437253,0.00001362183],"category_scores_gemma":[0.0001109545,0.0001537982,0.00004290595,0.00004697056,0.00003251003,0.00001154824,0.00009465697,0.0001195235,0.000004946377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002182869,"about_ca_system_score_gemma":0.00005516994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001872345,"about_ca_topic_score_gemma":0.0000333251,"domain_scores_codex":[0.9988679,0.0001468829,0.0002141298,0.0003708877,0.0001868504,0.0002133423],"domain_scores_gemma":[0.9992726,0.00003217828,0.0001710344,0.0002941579,0.0001027117,0.0001272822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005633751,0.0000580216,0.00474954,0.00001468219,0.00002873978,0.00000111486,0.0002843522,0.00002045835,0.9937853,0.00004474971,0.0002233106,0.0007333593],"study_design_scores_gemma":[0.0009117973,0.0001712693,0.002041354,0.00001889797,0.0000306492,0.000001326678,0.000155888,0.002088872,0.993748,0.0003460056,0.0002984439,0.0001874843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888236,0.001096423,0.009132752,0.00005383376,0.0001173826,0.0005009581,0.00005075794,0.00002317745,0.0002011242],"genre_scores_gemma":[0.9982281,0.00002927841,0.0003158977,0.00005870227,0.0002360111,0.00006973346,0.0008179496,0.00002354737,0.0002207915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009404497,"threshold_uncertainty_score":0.627171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01860434002704085,"score_gpt":0.2185354363823885,"score_spread":0.1999310963553477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}