{"id":"W2037220161","doi":"10.1089/hum.2010.195","title":"Autologous Transplantation of Lentivector/Acid Ceramidase–Transduced Hematopoietic Cells in Nonhuman Primates","year":2011,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Genetic enhancement; Haematopoiesis; Ceramide; Viral vector; Spleen; Biology; Transplantation; Bone marrow; Sphingolipid; Glucocerebroside; Lysosomal storage disease; Cancer research; Hematopoietic stem cell transplantation; Immunology; Stem cell; Medicine; Pathology; Internal medicine; Disease; Cell biology; Gene; Glucocerebrosidase; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006136599,0.0006736998,0.0005735037,0.0009440091,0.0006495784,0.0006083081,0.0005520202,0.0009662607,0.003414305],"category_scores_gemma":[0.0002790638,0.0002927456,0.0003336679,0.000352795,0.0007084186,0.0004808905,0.0003600183,0.001168075,0.001011611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003928648,"about_ca_system_score_gemma":0.0004210915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009955965,"about_ca_topic_score_gemma":0.0009225791,"domain_scores_codex":[0.999632,0.00007620029,0.00002925213,0.0001092685,0.00009617327,0.0000571649],"domain_scores_gemma":[0.9997295,0.00005053488,0.00005997938,0.00007272241,0.00002401474,0.00006319745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001768819,0.001174499,0.0005590421,0.0001662276,0.00003733181,0.0009275504,0.0002970265,0.0004504017,0.981107,0.0012575,0.0004570059,0.01179762],"study_design_scores_gemma":[0.0006199569,0.01296701,0.003059963,0.00007171511,0.0001209038,0.003139484,0.0001948125,0.002358838,0.9634251,0.000895765,0.01311527,0.00003112711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980202,0.003335734,0.008078761,0.0002665807,0.0001679604,0.0008301671,0.001016053,0.0004827553,0.005619994],"genre_scores_gemma":[0.9743904,0.002599325,0.01072028,0.0001563978,0.00004696007,0.0007489531,0.001359409,0.0001043277,0.009873943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003414305,"threshold_uncertainty_score":0.01142198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05644408928522237,"score_gpt":0.305546968248844,"score_spread":0.2491028789636216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}