{"id":"W2037220161","doi":"10.1089/hum.2010.195","title":"Autologous Transplantation of Lentivector/Acid Ceramidase–Transduced Hematopoietic Cells in Nonhuman Primates","year":2011,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Genetic enhancement; Haematopoiesis; Ceramide; Viral vector; Spleen; Biology; Transplantation; Bone marrow; Sphingolipid; Glucocerebroside; Lysosomal storage disease; Cancer research; Hematopoietic stem cell transplantation; Immunology; Stem cell; Medicine; Pathology; Internal medicine; Disease; Cell biology; Gene; Glucocerebrosidase; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001965945,0.0001889117,0.0003953361,0.000210767,0.00006422507,0.000008081687,0.000167358,0.0001096512,0.001244627],"category_scores_gemma":[0.000003313171,0.0001705665,0.000117183,0.0002151162,0.0001554569,0.00007259508,0.000009014074,0.0001815184,0.00003228172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005945623,"about_ca_system_score_gemma":0.0000592799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002709559,"about_ca_topic_score_gemma":0.0000776386,"domain_scores_codex":[0.9985746,0.0001030348,0.0003790477,0.0002956823,0.0003125177,0.0003351122],"domain_scores_gemma":[0.9994224,0.00002047879,0.00008385105,0.0003024474,0.0000888155,0.0000819868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007299716,0.000772892,0.01184492,0.0002864885,0.00007000149,0.0001661756,0.01362858,0.000002166526,0.9702831,0.0002637736,0.00001332281,0.001938633],"study_design_scores_gemma":[0.003520612,0.000772564,0.143565,0.00006335213,0.00002269203,0.00003720715,0.0001313883,0.00001582057,0.8509637,0.0007531994,0.00001090618,0.0001435293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952344,0.001006773,0.0003301319,0.00002508158,0.00004485131,0.0007097651,0.0000105689,0.00006310341,0.002575371],"genre_scores_gemma":[0.9985397,0.0006014693,0.0004947963,0.00005771771,0.00002780538,0.00004359579,0.00004681752,0.00004202416,0.0001461155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1317201,"threshold_uncertainty_score":0.9996684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05644408928522237,"score_gpt":0.305546968248844,"score_spread":0.2491028789636216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}