{"id":"W2037247773","doi":"10.1007/s00424-013-1317-x","title":"Relative contribution of different transmembrane segments to the CFTR chloride channel pore","year":2013,"lang":"en","type":"article","venue":"Pflügers Archiv - European Journal of Physiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Chemistry; Cysteine; Extracellular; Biophysics; Cystic fibrosis transmembrane conductance regulator; Transmembrane protein; Ion channel; Chloride channel; Transmembrane domain; Mutagenesis; Intracellular; Gating; Membrane; Crystallography; Biochemistry; Mutant; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004714892,0.0001773208,0.0005354306,0.0001754798,0.00007687517,0.000009840544,0.0003208549,0.00001852321,0.0001309454],"category_scores_gemma":[0.000491961,0.00009945394,0.0002257868,0.000159516,0.0002506567,0.0001311342,0.00008394894,0.0004838852,0.00007130916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005013652,"about_ca_system_score_gemma":0.00005011622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008272924,"about_ca_topic_score_gemma":0.000001364422,"domain_scores_codex":[0.9978021,0.0006143496,0.0006413583,0.0001842142,0.0003811326,0.000376891],"domain_scores_gemma":[0.9983681,0.0003617519,0.0003795869,0.0002563387,0.0003429812,0.0002912634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001860658,0.0001819746,0.00007494176,0.00006032743,0.000246014,0.00004173355,0.001189529,0.0002350012,0.9894725,0.0001169103,0.00124627,0.00527411],"study_design_scores_gemma":[0.007604502,0.01087274,0.6008298,0.001131375,0.0002672899,0.0003986103,0.0009419961,0.0006316271,0.3664238,0.004409907,0.006139517,0.0003488522],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900691,0.0002304733,0.003136131,0.004929926,0.0002868615,0.0005695506,0.00001902998,0.000009267992,0.0007496739],"genre_scores_gemma":[0.9984623,0.0001794784,0.0004688874,0.0002910417,0.0003473307,0.00000579522,0.00002268688,0.00002628584,0.0001962489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6230487,"threshold_uncertainty_score":0.4055614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304727300429312,"score_gpt":0.2634478854795493,"score_spread":0.2504006124752561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}