{"id":"W2037277769","doi":"10.1021/ja303529z","title":"Total Synthesis of the Potent cAMP Signaling Agonist (−)-Alotaketal A","year":2012,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; University of Colorado Boulder; University of British Columbia; Texas A and M University; Welch Foundation","keywords":"Chemistry; Agonist; Stereochemistry; Alkene; Total synthesis; Receptor; Biochemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003042332,0.0001088231,0.0002102783,0.00000457157,0.00007053302,0.000008068624,0.0003812014,0.00005158526,0.000009098808],"category_scores_gemma":[0.0002960879,0.00005505653,0.0007117179,0.0001417242,0.0003289746,0.000004897292,0.0002666695,0.0002503193,4.861072e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003097806,"about_ca_system_score_gemma":0.0000572103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002150838,"about_ca_topic_score_gemma":2.454092e-7,"domain_scores_codex":[0.9991286,0.00006057021,0.0002600316,0.00009483163,0.0002453533,0.0002106388],"domain_scores_gemma":[0.9989625,0.00003434411,0.0005778141,0.0002505511,0.0001000629,0.00007478154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004792762,0.00006487973,0.004795062,0.00001019702,0.0001289386,1.084309e-7,0.0000497179,0.00001467605,0.9899378,0.000003697827,0.002629315,0.002317672],"study_design_scores_gemma":[0.0001106163,0.00004588443,0.01163469,0.00001785157,0.00007720312,0.00009501275,0.0001649516,0.000007823621,0.985137,0.000009351695,0.002616953,0.00008260539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976348,0.0004590749,0.00001093773,0.001500641,0.0002143418,0.00005125666,0.000005993631,0.000001475169,0.0001214328],"genre_scores_gemma":[0.9980044,0.00006808058,0.000644011,0.0003624421,0.0007741081,9.069595e-7,6.626825e-7,0.00001117456,0.0001341619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006839631,"threshold_uncertainty_score":0.224514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006655901358488509,"score_gpt":0.2274952987878172,"score_spread":0.2208393974293287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}