{"id":"W2037282195","doi":"10.1016/j.bcp.2014.12.008","title":"Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II)","year":2014,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; St. John's University","keywords":"Cytotoxicity; Drug; Pharmacology; Chemistry; Anticancer drug; Cancer research; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001302114,0.0002288573,0.0002776617,0.0002314974,0.0002133606,0.0003057638,0.0003367643,0.0003517424,0.001718858],"category_scores_gemma":[0.0001477781,0.0001595608,0.000238782,0.000214798,0.0003481705,0.0003132179,0.0001276648,0.0004943113,0.0003298749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005710179,"about_ca_system_score_gemma":0.0003196129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010828,"about_ca_topic_score_gemma":0.001049837,"domain_scores_codex":[0.9998882,0.00003545585,0.000007503152,0.00001368674,0.00001725635,0.00003784311],"domain_scores_gemma":[0.9999217,0.0000226438,0.00001609026,0.00001415399,0.00001460236,0.000010762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002285807,0.000191386,0.0005327038,0.0002264762,0.00002776625,0.0002687192,0.00009506317,0.000340932,0.988465,0.001961867,0.0002997116,0.00530451],"study_design_scores_gemma":[0.00006064628,0.0007619124,0.00375614,0.00001208181,0.00003322601,0.0002705771,0.00008862947,0.000940376,0.9918877,0.0002281632,0.00195284,0.000007592757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878698,0.005561478,0.002492467,0.0003404267,0.00004914668,0.00003258655,0.0002753698,0.0001252847,0.003253614],"genre_scores_gemma":[0.9963436,0.001252899,0.0003635024,0.00003461194,0.00001096241,0.0000206123,0.0001610557,0.000004703891,0.001808234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718858,"threshold_uncertainty_score":0.00575012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02658752419172968,"score_gpt":0.2606082908508118,"score_spread":0.2340207666590821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}