{"id":"W2037284826","doi":"10.1021/jm300677j","title":"Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Chemistry; Demethylation; Daminozide; Regulator; Oxygenase; Stereochemistry; Hydroxylation; Biochemistry; Plant growth; Enzyme; Botany; Gene; Biology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006062132,0.0001610034,0.00030666,0.00004967613,0.00005228667,0.00000489218,0.0001739152,0.0001944672,0.00005145705],"category_scores_gemma":[0.0003270058,0.0001372606,0.0001558249,0.00009070653,0.0001241697,0.00000943989,0.00004773837,0.0002143066,6.994175e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004993234,"about_ca_system_score_gemma":0.0001425484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000118608,"about_ca_topic_score_gemma":9.566662e-7,"domain_scores_codex":[0.9986109,0.00004402602,0.0005697805,0.0001405215,0.0004017781,0.0002330341],"domain_scores_gemma":[0.9985324,0.00003346995,0.0006564386,0.0001767544,0.0003768282,0.0002241505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001365895,0.0001466642,0.01632823,0.0001025364,0.0001034808,0.000004989716,0.000195576,0.000001488434,0.9795463,0.000008114706,0.003126828,0.0002992123],"study_design_scores_gemma":[0.0007639813,0.0004611959,0.00734972,0.00009427524,0.0001076887,0.00009721221,0.0001626875,0.000001796692,0.987274,0.0001011799,0.003452013,0.0001342517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872536,0.01127122,0.0002277742,0.0001006455,0.0001726844,0.00004712532,0.00001802137,0.000002446194,0.0009064889],"genre_scores_gemma":[0.99697,0.0003209376,0.0005195182,0.0000643747,0.001792769,0.000001731158,0.00002708953,0.00001872038,0.0002848616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01095029,"threshold_uncertainty_score":0.5597326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289873265581554,"score_gpt":0.2862890994708638,"score_spread":0.2733903668150483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}