{"id":"W2037284826","doi":"10.1021/jm300677j","title":"Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Chemistry; Demethylation; Daminozide; Regulator; Oxygenase; Stereochemistry; Hydroxylation; Biochemistry; Plant growth; Enzyme; Botany; Gene; Biology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139325,0.0003280299,0.000277735,0.0002520711,0.0001340299,0.00009315703,0.0002406575,0.0001494933,0.0008860687],"category_scores_gemma":[0.00008520899,0.0001289573,0.0001308393,0.0001832011,0.0001366448,0.0000861447,0.0001327883,0.000372856,0.0002364228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002454668,"about_ca_system_score_gemma":0.0001994188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005194155,"about_ca_topic_score_gemma":0.001954278,"domain_scores_codex":[0.9999292,0.00001302877,0.000005255973,0.00001299772,0.00002492521,0.00001457566],"domain_scores_gemma":[0.9999543,0.000009273601,0.000009723481,0.000006549906,0.000006067884,0.00001403549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001429405,0.00004666531,0.0001945299,0.00004835775,0.00001015695,0.00003985736,0.000009142163,0.0001256997,0.995486,0.00006565361,0.0001177293,0.003713227],"study_design_scores_gemma":[0.00007347415,0.0006591468,0.001940238,0.000003267051,0.0000190817,0.0002083379,0.000007393367,0.000425639,0.9926152,0.00002458765,0.004020154,0.000003509805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817132,0.005562109,0.00706642,0.0002166102,0.00004867875,0.0001670229,0.0008506562,0.0003590067,0.004016346],"genre_scores_gemma":[0.9862554,0.003118974,0.005766184,0.00007628446,0.00001403395,0.00008121833,0.001478791,0.00001993696,0.003189192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008860687,"threshold_uncertainty_score":0.002964258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289873265581554,"score_gpt":0.2862890994708638,"score_spread":0.2733903668150483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}