{"id":"W2037287070","doi":"10.1021/bi9013819","title":"SDS Micelles as a Membrane-Mimetic Environment for Transmembrane Segments","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Micelle; Chemistry; Sodium dodecyl sulfate; Circular dichroism; Transmembrane protein; Peptide; Denaturation (fissile materials); Membrane protein; Lipid bilayer; Transmembrane domain; Biophysics; Peripheral membrane protein; Native state; Protein secondary structure; Membrane; Biochemistry; Integral membrane protein; Aqueous solution; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002456249,0.0003352606,0.0001778865,0.000236378,0.0001651661,0.0002585045,0.0001956717,0.0002063276,0.0003956461],"category_scores_gemma":[0.0001883932,0.0001281224,0.0001193129,0.000155255,0.0001718528,0.0002597584,0.0001503007,0.0003323659,0.0002629348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001693347,"about_ca_system_score_gemma":0.0001541815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002522199,"about_ca_topic_score_gemma":0.0003541195,"domain_scores_codex":[0.9998522,0.00005780003,0.00001667216,0.00002570885,0.00003503406,0.00001261072],"domain_scores_gemma":[0.999893,0.00002699117,0.00003254757,0.000007830316,0.00002668992,0.00001297679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002869951,0.00001091608,0.000121823,0.00002726014,0.00000256464,0.00002863504,0.00001430437,0.00005825465,0.9993137,0.0001104247,0.00001083795,0.0002724882],"study_design_scores_gemma":[0.000007051211,0.0001176351,0.0003801722,0.000004890253,0.000006281875,0.00008846836,0.00001789214,0.0005169986,0.9976446,0.00003893093,0.001174803,0.000002266175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855399,0.002631413,0.009854256,0.0001263275,0.00003834365,0.00009383132,0.0001690717,0.0001108875,0.001435978],"genre_scores_gemma":[0.9860981,0.001895701,0.009750674,0.00007705297,0.00001515171,0.00007973108,0.0004619476,0.00002316981,0.001598603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003956461,"threshold_uncertainty_score":0.001323581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006575084529719927,"score_gpt":0.2401909792158371,"score_spread":0.2336158946861172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}