{"id":"W2037319774","doi":"10.1021/ja9102925","title":"Chemical Synthesis and Biological Activity of the Neopetrosiamides and Their Analogues: Revision of Disulfide Bond Connectivity","year":2010,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia","funders":"","keywords":"Chemistry; Disulfide bond; Norleucine; Diastereomer; Solid-phase synthesis; Biological activity; Stereochemistry; Methionine; Sulfoxide; Cysteine; Peptide; Chemical synthesis; Combinatorial chemistry; Peptide synthesis; Amino acid; Biochemistry; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002289664,0.0001331781,0.0003474767,0.00000591019,0.00004724099,0.000009074268,0.000272361,0.0001340511,0.00000211258],"category_scores_gemma":[0.0008178842,0.00006149865,0.0003200776,0.0001250386,0.001287097,0.000007966079,0.0002962249,0.0003174408,1.934139e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009504618,"about_ca_system_score_gemma":0.00003235825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001285992,"about_ca_topic_score_gemma":9.71044e-7,"domain_scores_codex":[0.999266,0.00006764037,0.0002627753,0.0001633038,0.0001207804,0.0001194675],"domain_scores_gemma":[0.998812,0.000177679,0.0006372094,0.0002084213,0.00009937556,0.0000653535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001133911,0.00003884664,0.01609712,0.0000233418,0.00005063134,4.419473e-8,0.00004348755,1.038087e-7,0.9787729,0.000007946815,0.0001041265,0.004748033],"study_design_scores_gemma":[0.0001326841,0.00005726421,0.06297813,0.00003189733,0.00002701975,0.000038563,0.00006372583,0.00001629168,0.9363278,0.0001076355,0.0001447036,0.00007430559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990113,0.0001135439,0.00005919053,0.0006675812,0.00004873015,0.0000594829,0.000031475,0.000001663439,0.000007033459],"genre_scores_gemma":[0.9988874,0.0002995057,0.000540674,0.000137278,0.0001244201,6.495019e-7,0.000001807929,0.000006386355,0.000001930743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04688101,"threshold_uncertainty_score":0.4742364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007356406689868001,"score_gpt":0.2238294583105487,"score_spread":0.2164730516206807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}