{"id":"W2037343509","doi":"10.1021/bi034491m","title":"Monomers and Oligomers of the M<sub>2</sub> Muscarinic Cholinergic Receptor Purified from <i>Sf</i>9 Cells","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Centre for Addiction and Mental Health","keywords":"Receptor; Immunoprecipitation; Sepharose; Chemistry; Sf9; Muscarinic acetylcholine receptor; Chaps; Affinity chromatography; Monomer; Biochemistry; Digitonin; Muscarinic acetylcholine receptor M1; Molecular biology; Chromatography; Recombinant DNA; Biology; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003083831,0.0005522978,0.0003775773,0.0003061803,0.0002377139,0.0004278129,0.0003209218,0.000332906,0.001868405],"category_scores_gemma":[0.0001651856,0.0002098287,0.0004434549,0.0003672459,0.0001580266,0.000271151,0.0002208221,0.0008603861,0.001353196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003728456,"about_ca_system_score_gemma":0.0001576924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000900826,"about_ca_topic_score_gemma":0.001451178,"domain_scores_codex":[0.9996507,0.0000384399,0.00005885212,0.00008664068,0.0000879856,0.00007743059],"domain_scores_gemma":[0.9998654,0.00002841423,0.00002815638,0.00002739346,0.00002509233,0.00002547808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004355873,0.00001755569,0.0001453992,0.00002659286,0.000005724396,0.00003285735,0.00001886067,0.00001426911,0.9992685,0.00004677044,0.00004561487,0.0003342815],"study_design_scores_gemma":[0.00004017902,0.0004235068,0.01423225,0.00002039703,0.00004752757,0.0007471245,0.00008337396,0.001062012,0.9746439,0.0001053828,0.008581573,0.00001270097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821656,0.002610678,0.008248969,0.0001881411,0.0001079272,0.0001197764,0.00274021,0.0001451826,0.003673355],"genre_scores_gemma":[0.9458923,0.003314553,0.01799478,0.0003170834,0.0001034723,0.0002286974,0.01952359,0.0001343677,0.01249112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001868405,"threshold_uncertainty_score":0.006250381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005713073942117083,"score_gpt":0.1838230509160995,"score_spread":0.1781099769739825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}