{"id":"W2037343509","doi":"10.1021/bi034491m","title":"Monomers and Oligomers of the M<sub>2</sub> Muscarinic Cholinergic Receptor Purified from <i>Sf</i>9 Cells","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Centre for Addiction and Mental Health","keywords":"Receptor; Immunoprecipitation; Sepharose; Chemistry; Sf9; Muscarinic acetylcholine receptor; Chaps; Affinity chromatography; Monomer; Biochemistry; Digitonin; Muscarinic acetylcholine receptor M1; Molecular biology; Chromatography; Recombinant DNA; Biology; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472206,0.0002144524,0.000193525,0.00001640234,0.00007709138,0.00001966592,0.0002357264,0.0002702861,0.00005665332],"category_scores_gemma":[0.00006182835,0.0001793297,0.0001551509,0.0001024836,0.0001293793,0.00000319794,0.00009668948,0.0001292771,0.00000447323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001440227,"about_ca_system_score_gemma":0.00008997537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001634129,"about_ca_topic_score_gemma":0.000001520684,"domain_scores_codex":[0.9988461,0.00005126221,0.0002713657,0.0004413583,0.000145838,0.0002441056],"domain_scores_gemma":[0.9991628,0.00001593342,0.0001626601,0.0004907312,0.00005275897,0.0001151413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002290296,0.00003218352,0.0002170558,0.00002375867,0.00005193917,3.374525e-7,0.00002680397,0.00002030776,0.9982772,0.00001527787,0.0008327957,0.0004794131],"study_design_scores_gemma":[0.0004273267,0.00003214511,0.00006507868,0.00002294702,0.00002524861,0.000002724251,0.000149564,0.000008545763,0.9949238,0.00004449524,0.0040837,0.0002144473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968087,0.001838065,0.00006601535,0.00002905007,0.0003288611,0.0001159993,0.00005839542,0.000009008807,0.0007458794],"genre_scores_gemma":[0.9983097,0.000652621,0.0004305048,0.0001235325,0.0001529879,0.00001369363,0.00005789281,0.00002914915,0.0002298817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003353446,"threshold_uncertainty_score":0.7312852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005713073942117083,"score_gpt":0.1838230509160995,"score_spread":0.1781099769739825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}