{"id":"W2037368323","doi":"10.1021/cn200096u","title":"Transformation of Pro-Leu-Gly-NH<sub>2</sub> Peptidomimetic Positive Allosteric Modulators of the Dopamine D<sub>2</sub> Receptor into Negative Modulators","year":2012,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institutes of Health","keywords":"Allosteric regulation; Allosteric modulator; Chemistry; Stereochemistry; Peptidomimetic; Steric effects; Dopamine; Receptor; Biochemistry; Biology; Neuroscience; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000338142,0.000289814,0.0003136682,0.00006570849,0.0001209123,0.00002059098,0.0005105855,0.0001956374,0.000003775072],"category_scores_gemma":[0.0003318716,0.0002260202,0.0002021723,0.0005074624,0.0004703636,0.00006267978,0.0002207043,0.0002019438,0.000003206522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003858481,"about_ca_system_score_gemma":0.00007143001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007169355,"about_ca_topic_score_gemma":8.175105e-7,"domain_scores_codex":[0.9979219,0.0001289776,0.000537084,0.0004676722,0.000483236,0.0004611426],"domain_scores_gemma":[0.998843,0.00004798912,0.0003382604,0.0004180823,0.0001742714,0.0001783794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000837165,0.0001337547,0.0002426815,0.00004448584,0.00001149883,1.749833e-7,0.0004199036,0.0001077301,0.9971008,0.0001167049,0.0000209195,0.001717653],"study_design_scores_gemma":[0.000406088,0.0002313323,0.0007453621,0.00005200648,0.00002937616,0.00001006591,0.00008985736,0.0004659439,0.9975701,0.000119732,0.00003574596,0.0002444196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970776,0.00008531462,0.001744741,0.00007615094,0.0004274181,0.000486662,0.00003032454,0.00001327949,0.00005849288],"genre_scores_gemma":[0.9992006,0.00008421067,0.0003344919,0.0001817594,0.000109338,0.00002978052,0.00002227568,0.00003095016,0.000006538172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002123039,"threshold_uncertainty_score":0.9216835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0086222715302548,"score_gpt":0.2193583387443057,"score_spread":0.2107360672140509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}