{"id":"W2037374227","doi":"10.1038/ncomms1237","title":"The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain","year":2011,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"CpG site; Chromatin; Biology; DNA; Histone; DNA methylation; Cell biology; Biochemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283235,0.0003184622,0.0002507279,0.00008333656,0.0004385743,0.0002478097,0.0006206091,0.0006542079,0.001952438],"category_scores_gemma":[0.0002538309,0.000238678,0.0002690086,0.00007398757,0.0004269948,0.0003067699,0.0004075074,0.0007559374,0.0004000396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004489207,"about_ca_system_score_gemma":0.0004677735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001567196,"about_ca_topic_score_gemma":0.001326243,"domain_scores_codex":[0.9998956,0.0000105012,0.000005319708,0.00002313325,0.00003391923,0.0000315043],"domain_scores_gemma":[0.9998909,0.00002121711,0.00002608326,0.00001048646,0.00001420477,0.00003710854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000262626,0.00007834486,0.001402888,0.0001634491,0.00001957646,0.0007351684,0.00005618701,0.002122573,0.9873438,0.004442138,0.0004118293,0.00296161],"study_design_scores_gemma":[0.0002497915,0.0003669519,0.01619217,0.00003446584,0.000039503,0.001507256,0.0001160138,0.02457262,0.9484054,0.002863188,0.00560882,0.00004390505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988281,0.00135495,0.006453838,0.0005040847,0.00008118839,0.00005531996,0.0001516329,0.0001219122,0.002996115],"genre_scores_gemma":[0.9967603,0.0003361968,0.002011828,0.0001054573,0.00001017872,0.00001861375,0.0001521377,0.00001312214,0.0005920993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001952438,"threshold_uncertainty_score":0.006531537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491215305425324,"score_gpt":0.2970483589497404,"score_spread":0.2821362058954872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}