{"id":"W2037374227","doi":"10.1038/ncomms1237","title":"The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain","year":2011,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"CpG site; Chromatin; Biology; DNA; Histone; DNA methylation; Cell biology; Biochemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003939351,0.00009652482,0.00008604788,0.00002306967,0.0005401258,0.0000169363,0.0007909673,0.0002324246,0.000002828267],"category_scores_gemma":[0.0002287886,0.00005954789,0.00008698422,0.0001616987,0.0001675838,0.000003275849,0.0001647741,0.0002746647,5.953475e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001271768,"about_ca_system_score_gemma":0.00004538571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002264208,"about_ca_topic_score_gemma":0.0002185162,"domain_scores_codex":[0.9993283,0.0001330798,0.000186559,0.0001327617,0.00007851978,0.0001407454],"domain_scores_gemma":[0.9983914,0.0001993404,0.0001534959,0.0009934434,0.0002373288,0.00002500053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009480814,0.00004711734,0.006017842,0.000006367237,0.0002100183,2.87639e-8,0.001026069,0.000003095527,0.9795279,0.00384543,0.004417004,0.004804336],"study_design_scores_gemma":[0.000462792,0.0002298042,0.01812073,0.000009824391,0.00006250116,0.000001323928,0.0005205832,0.0003774201,0.9268578,0.003825759,0.0493457,0.0001857605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648672,0.01994734,0.004468466,0.00108453,0.0002442682,0.0008217914,0.0003280846,0.0000138939,0.008224375],"genre_scores_gemma":[0.9931637,0.0007906487,0.005432007,0.00005221501,0.00003512442,0.00009065343,0.0002397296,0.00001453016,0.000181384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05267008,"threshold_uncertainty_score":0.4154266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491215305425324,"score_gpt":0.2970483589497404,"score_spread":0.2821362058954872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}