{"id":"W2037387936","doi":"10.1097/qai.0b013e3181cbd235","title":"Connection Domain Mutations in Treatment-Experienced Patients in the OPTIMA Trial","year":2010,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Canadian Institutes of Health Research","funders":"Canadian Institutes of Health Research","keywords":"Abacavir; Reverse transcriptase; Zidovudine; Stavudine; Population; Medicine; Lamivudine; Internal medicine; Virology; Reverse-transcriptase inhibitor; Univariate analysis; Viral load; Regimen; Genotype; Multivariate analysis; Immunology; Biology; Human immunodeficiency virus (HIV); Viral disease; Virus; Antiretroviral therapy; Genetics; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001093561,0.0001922733,0.0005242217,0.0001418073,0.0003174582,0.0007949826,0.0001652703,0.0004309244,0.001639711],"category_scores_gemma":[0.001543757,0.0001583305,0.0004675464,0.0001968441,0.0002434328,0.000380656,0.000219562,0.0006981652,0.0001442676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002502903,"about_ca_system_score_gemma":0.0002666622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002199207,"about_ca_topic_score_gemma":0.0005587302,"domain_scores_codex":[0.9994974,0.0002386004,0.00003950576,0.0001015562,0.00005694507,0.00006587066],"domain_scores_gemma":[0.9993244,0.0001825405,0.0002383399,0.00003322129,0.00002576625,0.000195702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1919051,0.002222668,0.705537,0.0004111014,0.001908062,0.0007191958,0.0003188818,0.001743038,0.0111818,0.0005981784,0.003945696,0.07950931],"study_design_scores_gemma":[0.04516946,0.04463486,0.8921351,0.0002544919,0.001713448,0.002955533,0.0002849082,0.003340835,0.002101674,0.001109598,0.006226701,0.0000734259],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975718,0.001173243,0.00006718649,0.0001620029,0.00001860157,0.00002990215,0.0001860182,0.000005052128,0.0007862478],"genre_scores_gemma":[0.9989354,0.0002015971,0.0001464308,0.0001617753,0.00003838053,0.0000374077,0.0002753402,0.000002051233,0.0002016006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001639711,"threshold_uncertainty_score":0.005783379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618629033370632,"score_gpt":0.2869363073313971,"score_spread":0.2707500169976908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}